Chemistry: physical processes – Physical processes – Crystallization
Patent
1977-11-21
1979-04-03
Wolk, Morris O.
Chemistry: physical processes
Physical processes
Crystallization
252408, 422 56, G01N 3316
Patent
active
041475143
ABSTRACT:
Test means, method of making a test device and process for detection of ketone bodies are disclosed. More particularly, suitable test means are of the type having a nitroprusside in combination with at least one inorganic salt of a metal selected from the group of magnesium and calcium. Optionally, at least one primary amine is combined therewith. The compositions are advantageously incorporated with a carrier, such as a matrix or tablet, to provide a test device. The metal salt stabilizes the nitroprusside in solution at alkaline pH, allowing for a single-dip production method, promotes ionization of ketone bodies, resulting in a shortened reaction time, and stabilizes the resulting chromophoric complex. The chromophoric complex is further stabilized by the primary amine.
REFERENCES:
patent: 2509140 (1950-05-01), Free
patent: 2577978 (1951-12-01), Nicholls et al.
patent: 2990253 (1961-06-01), Smeby
patent: 3212855 (1965-10-01), Rebar, Jr. et al.
patent: 3880590 (1975-04-01), Ogawa et al.
Magers Thomas A.
Tabb David L.
Herron Charles J.
Miles Laboratories Inc.
Turk Arnold
Wolk Morris O.
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