Test kit for intracellular introduction of protein and/or...

Details Test kit for intracellular introduction of protein and/or... Test kit for intracellular introduction of protein and/or...

2007-08-07

2007-08-07

Lilling, Herbert J (Department: 1657)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C536S023100, C435S006120, C435S007100, C435S007920, C435S320100

Reexamination Certificate

active

10671881

ABSTRACT:
A test kit for intracellular introduction of a protein and/or peptide and a method of such intracellular introduction, make it possible for a protein and/or peptide to be introduced into cells efficiently and in an expedient manner while preventing the function of the introduction target protein and/or peptide from being reduced. The above test kit comprises a container containing a cationic group-containing polymer and a container containing a reagent for coupling or binding the cationic group-containing polymer to the protein and/or peptide, or comprises a container containing a cationized conjugate to be coupled to the protein and/or peptide. The above method comprises using a conjugate generated by coupling or binding a cationic group-containing polymer to a protein and/or peptide as a carrier for the introduction target protein and/or peptide.

REFERENCES:
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patent: 2005/0059031 (2005-03-01), Bruchez et al.
patent: 1 316 318 (2003-06-01), None
patent: WO 01/43778 (2001-06-01), None
patent: WO 02/10201 (2002-02-01), None
Futami, J., et al, Preparation of Potent Cytotoxic Ribonucleases by Cationization: Enhanced Cellular Uptake and Decreased Interaction with Ribonuclease Inhibitor by Chemical Modification of Carboxyl Groups, Biochemistry 2001, 40: 7518-7524.
Schwarze, S.R., et al, In Vivo Protein Transduction: Delivery of a Biologically Active Protein into the Mouse, Science, vol. 285, No. 5433, Sep. 3, 1999: 1569-1572.
Futaki, S., et al, Arginine-rich Peptides, The Journal of Biological Chemistry, vol. 276, No. 8, Feb. 23, 2001: 5836-5840.

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