Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1980-04-11
1982-08-24
Fagelson, Anna P.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
435 29, A61K 4900, C12Q 100
Patent
active
043460704
ABSTRACT:
A novel method for determining the teratogenic potential of an agent of unknown teratogenic effect is described. This novel method comprises the steps of providing a plurality of artificial embryos, chronically exposing the embryos to varying concentrations of test agents, observing the exposed embryos over time to estimate a minimum teratogenic concentration of the test agent required to interfere with the development of the embryo, and comparing the minimum teratogenic concentration to a minimum adult reference concentration of the test agent which is toxic to normal adults. In this manner, the teratogenic potential of the test compound is indicated by the degree of difference between the teratogenic and adult reference concentrations.
REFERENCES:
"Screening for Teratogenic Hazards: Nature of the Problems", E. Marshall Johnson, Ann. Rev. Pharmacol. Toxicol., 1981, 21:417-429.
"Screening for Teratogenic Potential: Are We Asking the Proper Question?", E. Marshall Johnson, Teratology 21:259 (1980).
"A Subvertebrate System for Rapid Determination of Potential Teratogenic Hazards," E. Marshall Johnson, Journal of Environmental Pathology and Toxicology 4:153-156 (1980).
"Practical Application of Systems for Rapid Detection of Potential Teratogenic Hazards", E. Marshall Johnson, In Press-Advances of Modern Toxicology, vol. 2.
Johnson, Am. Asso. Anatomists, Abstract of Papers reprint from The Anatomical Record, vol. 196, No. 3, Mar. 1980, p. 89A.
Loomis, J. Exp. Zool., vol. 132, 1956, pp. 555-573.
Gierer, Nature, New Biol., vol. 239, Sep. 27, 1972, pp. 98-105.
Wakeford, J. Embryol. Exp. Morph., vol. 54, 1979, pp. 171-183.
Lee, Biol. Bull., vol. 157, Oct. 1979, pp. 288-296.
Sugiyama, Develop. Growth & Differ., vol. 21, 1979, pp. 361-375.
Epp, Trans. Amer. Micros. Soc., vol. 98, No. 3, Jul. 1979, pp. 392-400.
Berking, J. Cell. Sci., vol. 40, 1979, pp. 193-205.
Webster, J. Embryol. Exp. Morph., vol. 27, No. 2, 1972, pp. 301-306.
Filskie, J. Cell. Sci., vol. 23, 1977, pp. 151-172.
David, Proc. Nat. Acad. Sci., (U.S.A.), vol. 75, Feb. 1978, pp. 886-890.
Yaross, J. Cell. Sci., vol. 34, 1978, pp. 1-26.
Gierer, Quart. Reviews of Biophy., vol. 10, 1977, pp. 529-593.
Berking, Wilhelm Roux's Arch., vol. 182, 1977, pp. 117-129.
Brode, J. Cell. Sci., vol. 20, 1976, pp. 29-46.
Schaller, Cell Differentiation, vol. 5, 1976, pp. 1-11, 13-20.
Lentz, J. Exp. Zool., vol. 159, 1965, pp. 181-194.
Burnett, (Ed.) Biol. of Hydra, 1973, pp. 255-267 (Acd. Press).
David, J. Cell. Sci., vol. 11, 1972, pp. 557-568.
Otto, J. of Exp. Zool., reprint, vol. 200, Jun. 1977, pp. 417-428.
Bode, Wilhelm Roux' Arch., vol. 171, 1973, pp. 269-285.
Wilson, Environmental Sci., Environment & Birth Defects, Acd. Press, N.Y., 1973, pp. 23-26.
Solomon, Developmental Biol., vol. 9, No. 3, Jun. 1964, pp. 315-326.
Ceron, J. Embryol. Exp. Morph., vol. 26, 1971, pp. 323-338.
Johnson, Organ & Tissue Spec. of Response to Teratogenic Insult, pub. in Neubert & Merker (Ed.), New Approaches to the Evaluation of Abnormal Embryonic Development, 2nd Sym. on Prenatal Develop., Sep. 1975, pub. Georg Thieme, Stuttgart, 1975, pp. 573-590.
Lenicque, Chem. Abs., vol. 67, 1967, Ab. No. 20417c.
Webster's 3rd New Int. Dict., unabridged, G&C Merriam Co., Springfield MA, 1963, pp. 438, 1110, 1421.
Edgar, Sci., vol. 198, Dec. 23, 1977, pp. 1285-1286.
Wilson, J. Environ. Path. & Toxicol., vol. 2, 1978, pp. 149-167.
Lenicque, Chem. Abs., vol. 69, 1968, Ab. No. 33770d.
Lenicque, Chem. Abs., vol. 76, 1972, Ab. No. 68712h.
Fagelson Anna P.
Thomas Jefferson University
LandOfFree
Test for teratogenic potential employing hydra does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Test for teratogenic potential employing hydra, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Test for teratogenic potential employing hydra will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1436545