Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving blood clotting factor
Patent
1993-02-22
1995-12-19
Redding, David A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving blood clotting factor
435 4, 435 23, 436 69, C12Q 156, C12Q 100, G01N 3386
Patent
active
054767717
ABSTRACT:
A quantitative method for determining the plasma levels of thrombin-specific inhibitors is based on the quantitative thrombin time using plasma dilutions, excess fibrinogen and thrombin. The plasma dilutions and excess fibrinogen act in concert to eliminate the effects that coagulopathies have on standard coagulation tests. The method is relatively simple and provides superior results to standard conventional tests. The method is suitable for performance in clinical hematology laboratories on a routine basis using commercially available instrumentation.
REFERENCES:
patent: 3912805 (1975-10-01), Cayzer et al.
patent: 4067777 (1978-01-01), Innerfield et al.
patent: 4302538 (1981-11-01), Autenrieth et al.
patent: 4379142 (1983-04-01), Port et al.
patent: 4442655 (1984-04-01), Stroetmann
patent: 4496653 (1985-01-01), Lill et al.
patent: 4668621 (1987-05-01), Doellgast
patent: 4767742 (1988-08-01), Dodt et al.
patent: 4952562 (1990-08-01), Klein et al.
patent: 5019393 (1991-05-01), Ito et al.
patent: 5053453 (1991-10-01), Ku
patent: 5118790 (1992-06-01), Winant et al.
patent: 5187102 (1993-02-01), Stocker et al.
patent: 5196404 (1993-03-01), Maraganone et al.
Haver, et al., "Characterization of Thrombin-Induced Contraction . . . ", ood Vessels 21:53-63 (1984).
Lefkovitz, et al., "Direct Thrombin Inhibitors . . . ", Circulation 90; No. 3, 1522-1536 (1994).
Markwardt, "Hiradin and Derivatives as Anticoagulant Agents", Thombosis and Haemostasis, Stuttgart, 1993.
Trapodi, et al., "Effects of Hirudin on Activated Thromboplastin . . . ", Thrombosis and Haemostasis, Stuttgartt, 1993.
Zoldhelyi, et al., "Recombinant Hiradinin Patients . . . ", Circulation 88:#5, 2015-2022 (1993).
Murphy et al.; Am-J-Physiol. 1980 Dec.; 239(6):H742-50. (Abstract).
Fenton et al., Clin. Chem. 32/2, 320-324 (1986).
Alving Barbara
Reid Thomas J.
Leary Louise N.
Moran John F.
Redding David A.
The United States of America as represented by the Secretary of
LandOfFree
Test for quantitative thrombin time does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Test for quantitative thrombin time, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Test for quantitative thrombin time will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-991622