Test for lupus anticoagulant

Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined... – Derived from snake

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436 69, A61K 3558

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active

057051984

ABSTRACT:
It was found that the use of a phospholipid dependent prothrombin activator purified from the venom of snakes belonging to the Elapidae family, especially members of the Oxyaranus and Psuedonaja genera is most useful in tests for the determination of Lupus Anticoagulant. Based on this, several clotting, chromogenic aria immunochromogenic tests have been developped.

REFERENCES:
patent: 4106992 (1978-08-01), Varirel et al.
patent: 4725673 (1988-02-01), Herring
patent: 5112949 (1992-05-01), Vukovich
patent: 5192689 (1993-03-01), Heinker et al.
patent: 5219995 (1993-06-01), Herzog et al.
Triplett et al. Clinical application of a functional array for protein C. Hematologic Pathology, 1 (4), 239-248. 1987.
Alving et al. Comparison between a one-point dilute phospholipid APTT and the dilute Russell Viper Venom time verification of Lupus Anticoagulants, Thrombosis and Haemostasis.67(6), 672-678. 1992.
D.A. Triplett et al., "Lupus Anticoagulants: Misnomer, Paradox, Riddle Epiphenomenon," Hematol. pathol. 2, 121-143, 1988.
P.E. Love et al., "Antiphospholipid Antibodies: Anticardiolipin and the Lupus Anticoagulant in Systemic Lupus Erythematosus (SLE) and in Non-SLE Disorders," Ann. Int. Med. 112, 682-698, 1990.
T. Exner et al., SSC Subcommittee for the Standardization of Lupus Anticoagulants, "Guidelines for Testing and Revised Criteria for Lupus Anticoagulants," Thromb. Haemost. 65, 320-322, 1991.
J. Rosing et al., "Inventory of Exogenous Prothrombin Activators," Thrombosis and Haemostasis 65, 627-630, 1991.
P.P. Masci et al., "Purification and Characterization of a Prothrombin Activator from the Venom of the Australian Brown Snake, Pseudonaja Textilis Textilis," Biochemistry International, 17, 825-835, 1988.
C.Y. Lee (ed.), Snake Venoms, pp. 15-40, Springer Verlag, Berlin, Heidelberg, New York (1979).
H. Hofmann et al., "Blood Coagulation Induced by the Venom of Bothrops atrox. 1. Identification, Purification, and Properties of a Prothrombin Activator," Biochemistry, 26, 772 (1987).
Journal of Biological Chemistry, vol. 261, No. 28, 5 Oct. 1986, pp. 13258-13267, H. Speijer et al. "Prothrombin Activation by an Activator from the Venom of Oxyuranus scutellatus (Taipan Snake)".
Thrombosis and Haemostasis, vol. 65, No. 3, 4 Mar. 1991, Stuttgart De, pp. 320-322, T. Exner et al., "Guidelines for Testing and Revised Criteria for Lupus Anticoagulants".
Thrombosis Research, vol. 3(6), 1973, pp. 705-714, G.G. Owen et al.
Thrombosis Research, vol. 1(6), 1972, pp. 559-568.
Govers-Rienslag, J.W.P. et al., "Haemostology", vol. 7, 1988, pp. 41-53, editor H. Pirkle et al., Marcel Dekko Inc., NY.
Thrombosis and Haemostasis, Speijer, H. et al., vol. 57(3), 1987 (Jun.), pp. 349-355.
Thrombosis and Haemostasis, vol. 42(1), Jul. 1979, p. 4000, #0954-abstract, Owen, W.G. et al.
Aust. N.Z.J. Med., vol. 18(3, s-pp1 #2), 1988, p. 430, abstract, Whitaker, AN etal.
Scopes, R.K. Protein Purification--Principles and Procedure, 2nd edition, pp. 1, 17-20, 41-42, pp. 50-54 Springer-Verlog, 1987.
Deutscher, M.P. (ed.), Methods in Enzymology, vol. 182--Guide for protein Purification, Academic Process, Inc., 1990, p. 285, pp. 292-295.
Fohlman, J., "Toxican", vol. 17, 1979, pp. 170-172.
Tibbals, J., "Anaesth Intro Core", vol. 20(1), Feb. 1992, pp. 28-32.
Chester A. et al., Toxicon, vol. 20 (2), 1982, pp. 501-504.
Lalloo, O. et al., Toxicon, vol. 30(5-6), 1992, p. 528.
Masci, PP et al., Thrombosis Research, vol. 59, 1990, pp. 859-870.
Walker, F.J. et al. Biochemistry, vol. 19, 1980, pp. 1020-1023.
Nakagak, T. et al., Thrombosis Research, vol. 65, 1992, pp. 105-116.
T. Morita et al., "Purification and Properties of Prothrombin Activator from the Venom of Echis carinatus", J. Biochem. 83, 559-570 (1978).

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