Chemistry: physical processes – Physical processes – Crystallization
Patent
1980-08-14
1982-09-14
Turk, Arnold
Chemistry: physical processes
Physical processes
Crystallization
23901, 23913, G01N 3368, G01N 3372
Patent
active
043493521
ABSTRACT:
The invention is a process for a rapid and precise colorimetric method for determination of the total glucosylated blood proteins. The method is especially adapted and useful as a clinical, diagnostic aid for identification, management and treatment for diabetics. The method essentially comprises use of phenylhydrazine derivatives as reagents to determine the extent of glucosylation of hemoglobin and other proteins in the blood samples tested. The adduct of the aldehyde sugar (glucose) and the hemoglobin possesses the ketoamine structure. This structure is readily detected colorimetrically after treatment with a phenylhydrazine to give the corresponding phenylhydrazone. Phenylhydrazine and 2,4-dinitrophenylhydrazine are preferred reagents for the diagnostic process.
REFERENCES:
patent: 4142855 (1979-03-01), Acuff
patent: 4268270 (1981-05-01), Gabbay et al.
Shriner et al., "The Systematic Identification of Organic Compounds", John Wiley & Sons, Inc., New York, 3rd Edition, 1948, pp. 116-117, A.U. 173.
Grammaticakis, Chemical Abstracts, vol. 46, 1952, No. 46:11133f.
Acharya Seetharama A.
Manning James M.
Berry E. Janet
Rockefeller University
Turk Arnold
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