Test for determining the dose response of a conjugated vaccine

Details Test for determining the dose response of a conjugated vaccine Test for determining the dose response of a conjugated vaccine

1994-06-02

1997-02-18

Housel, James C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

424 92, 4242561, 4242451, 42419711, 4242031, 4242341, 4241931, G01N 33554, A61K 4900

Patent

active

056041080

ABSTRACT:
The dosage response of humans to conjugate vaccines comprising a bacterial polysaccharide and a strongly-immunogenic carrier protein is determined in animals by coadministering to the animal unconjugated strongly-immunogenic carrier protein in an amount corresponding, on a weight-related basis, to that administered to the human.

REFERENCES:
patent: 4496538 (1985-01-01), Gordon
patent: 4619828 (1986-10-01), Gordon
patent: 4644059 (1987-02-01), Gordon
Vella, P. P. et al. "Immunogenicity of a New Haemophilus influenzae type b Conjugate Vaccine" Pediatrics 85(4 part 2):668-74, 1990.
John. J. Donnelly et al. "Immunogenicity of A Haemophilus influenzae polysaccharide-Neisseria meningitidis outer membrane protein complex conjugate vaccine", Journal of Immunology 145:3071-9, 1990.
Juhani Eskola, et al. "Simultaneous administration of Haemophilus influenzaetype b capsular polysaccharide-diphtheria tetanus-pertussis and inactivated poliovirus vaccinations of childhood". Pediatr. Infect. Dis. 7:480-4, 1988.

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