Test for determination of triiodothyronine

Details Test for determination of triiodothyronine Test for determination of triiodothyronine

1974-04-22

1976-06-08

Wolk, Morris O.

Chemistry: physical processes

Physical processes

Crystallization

424 15, 250303, G01N 3316, G21H 502

Patent

active

039618943

ABSTRACT:
A radioimmunoassay method for the determination of triiodothyronine in human and animal fluids and tissues, particularly in serum. The method involves the separation of triiodothyronine from its binding proteins using a dextran gel column followed by competitive binding between the freed triiodothyronine and radioactive labeled triiodothyronine which remain bound to the gel column for triiodothyronine-specific anti-serum. Bound and free labeled triiodothyronine are separated by washing the column and their ratio is determined based on the amount of radioactivity remaining in the column to that originally added thereto.

REFERENCES:
patent: 3659104 (1972-04-01), Gross et al.
patent: 3710117 (1973-01-01), Gross et al.
patent: 3711247 (1973-01-01), Adams
Surks et al., J. Clin. Invest., vol. 51, pp. 3104-3113 (1972).
Alexander et al., Clin. Chem., vol. 20, pp. 1353-1361 (1974).

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