Test for detecting and measuring the graves' disease-specific im

Chemistry: analytical and immunological testing – Thyroid hormone tests

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436503, 436504, 436506, 436512, 436529, 436804, 436811, 436825, G01N 3358, G01N 3360, G01T 100

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active

044725086

ABSTRACT:
An immunoassay for a specific antibody, particularly Graves' disease-specific antibody, in which interfering reactions by the reactive ends of similar antibodies are eliminated by the step of occluding the interfering reactive ends with an antibody against the interfering reactive ends.

REFERENCES:
Teng et al., Clin. Endocrinol., 6, (1977), 207-211.
DeBruin et al., ACTA Endocrinologica, 100, (1982), 245-251.
DeBruin et al., ACTA Endocrinologica, 102, (1983), 49-56.
Valente et al., Proc. Natl. Acad. Sci. U.S.A., 79, (1982), 6680-6684.
Yavin et al., Proc. Natl. Acad. Sci. U.S.A., 78, (1981), 3180-3184.
Kotulla, Aulbert, Meinhold, Adlkofer, Wenzel, Schleusener, Kruck, Kruck, "Methodological Approaches to Measuring Thyroid Stimulating Factors with a Radioligand Receptor Assay," Freie Universitat.
Bernard Rees Smith, Reginald Hall: "Thyroid-Stimulating Immunoglobulins in Graves' Disease," The Lancet, Aug. 24, 1974.
S. Quasim Mehdi, Joseph P. Kriss: "Preparation of Radiolabeled (TSI) by Recombining TSI Heavy Chains with .sup.125 I-Labeled Light Chains: Direct Evidence that the Product Binds to the Membrane Thyrotropin Receptor and Stimulates Adenulate Cyclase," Endocrinology, vol. 103, #1, (1978).
Yukio Ochi, Shiro Hosoda, Takashi Hachiya, Manabu Yoshimura, Tadayoshi Miyazaki, Yoshihiro Kajita, "Studies on a Receptor Assay for an Antibody to Human Thyroid Plasma Membrane," ACTA Endocrinologica, (1979).
Michizo Kishihara, Yoshinobu Nakao, Yasuto Baba, Shigeru Matsukura, Kanji Kuma, Takuo Fujita, "Interaction between Thyroid-Stimulating Immunoglobulins and Thyrotropin Receptors in Fat Cell Membranes," Journal of Clinical Endocrinology and Metabolism, vol. 49, (1979).
Junji Konishi, Yasuhiro Iida, Kanji Kasagi, Katsuji Ikekubo, Kanji Kuma, Kanji Torizuka, "Adipocyte-TSH-Receptor-related Antibodies in Graves' Disease Detected by Immunoprecipitation," Endocrinology, Japan, vol. 29, (1982).
Tien-Wen Tao, Joseph P. Kriss, "Membrane-Binding Antibodies in Patients with Graves' Disease and other Anteimmune Diseases," Journal of Clinical Endocrinology and Metabolism, vol. 55, (1982).
Beall, Chopra, Solomon, Kruger, "Serum Protein Inhibition of Thyrotropin Binding to Human Thyroid Tissue," Journal of Clinical Endocrinology and Metabolism, vol. 47, (1978).
Fenzi, Macchia, Bartalena, Mazzanti, Baschieri, DeGroot, "Radio-receptor Assay of TSH: Its Use to Detect Thyroid-Stimulating Immunoglobulins," J. Endocrinol. Invest., 1:17, (1978).
Endo, Amir, Ingbar, "Development and Evaluation of a Method for the Partial Purification of Immunoglobulins Specific for Graves' Disease," J. of Clinical Endocrinol. & Metab., vol. 52, (1981).
Bliddal, "A Stable, Reproducible Radioreceptor Assay for Thyrotropin Binding Inhibiting Immunoglobulins (TBII)," Scand. J. Clin. Lab. Invest., vol. 41, 441-449, (1981).
Biro, "Thyroid-Stimulating Antibodies in Graves' Disease and the Effect of Thyrotrophin-Binding Globulins on Their Determination," J. of Endocrinology, vol. 92, pp. 175-184, (1982).
Navarro, Gomez, Pastor, Soler, "Antibodies Against TSH Receptor in Graves' Disease: Relation Between cGMP/cAMP Release," B.7. Hormone Receptors, pp. 575-578.
Navarro, Gomez, Pastor, Soler, "Antibodies Against TSH Receptor in Graves' Disease: Evaluation by Release of cAMP," B.7. Hormone Receptors, pp. 571-574.
Shishiba, Ozawa, Ohtsuki, Shimuzu, "Discrepancy between Thyroid-Stimulating and Thyrotropin-Binding Inhibitory Activities of Graves' Immunoglobulin Gs Assessed in the Mouse," J. of Clinical Endocrinology and Metabolism, vol. 54, pp. 858-862, (1982).
Kishihara, Nakao, Baba, Kobayashi, Matsukura, Kuma, Fujita, "Interaction between Thyrotropin (TSH) Binding Inhibitor Immunoglobulins (TBII) and Soluble TSH Receptors in Fat Cells," J. of Clin. Endocrinology & Metabolism, vol. 52, p. 665, (1981).
Sato, Zakarija, McKenzie, "Influence of Normal Human IgG and of TSAb on the Binding of Thyrotropin to Thyroid Plasma Membranes," Endocrine Research Con. 5(4), 259-269, (1978).
Mehdi, "Evidence that Human Thyroid Stimulating Immunoglobulins-G of Graves' Disease are Antibodies to Human Thyroid Cell-Surface Antigens," Oxford Univ.

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