Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving urea or urease
Patent
1994-02-14
1995-08-08
Wityshyn, Michael G.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving urea or urease
435 1, 435 4, 435 10, 435 34, 436 63, 436811, G12Q 158, G01N 3348
Patent
active
054398010
ABSTRACT:
An improved test composition for the diagnosis of gastric disease by detecting the presence of urease associated with H. pylori in a biopsy specimen is described in which the hydrolysis of urea by urease is detected by a combination of at least two dye indicators showing a color change and a positive result at an acid pH, in which the positive color is distinctive from the color of the biopsy specimen, and in which most positive results occur in 2-10 minutes and all occur in no more than 4 hours. Specific compositions are disclosed.
REFERENCES:
patent: 3395082 (1968-07-01), Mast
patent: 3461036 (1969-08-01), Horcil
patent: 4101382 (1978-07-01), Chang
patent: 4282316 (1981-08-01), Modrovich
patent: 4748113 (1988-05-01), Marshall
patent: 5258178 (1993-11-01), Cordle et al.
patent: 5260057 (1993-11-01), Cordle et al.
patent: 5304540 (1994-04-01), Blackburn et al.
patent: 5314804 (1994-05-01), Boguslaski et al.
Helicobacter pylori in Peptic Ulceration and Gastritis Barry J. Marshall. Richard W. McCallum & Richard L. Guerraut, Blackwell Scientific Publication, Boston, Mass., USA, Chapters 4, 7 and 12.
"Marshall's Hunch", The New Yorker Magazine, pp. 64-72 Sep. 20, 1993.
"The Doctor Who Wouldn't Accept No", Readers Digest Magazine, pp. 120-124, Oct., 1993.
Annals of Internal Medicine, David Y. Graham, 1192; 116 No. 9.
Difco Manual, 9th Ed., Difco Laboratories, Detroit, Mich., 1952.
Helicobacter pylori, "Urease and Purification of its Subunits", D. G. Evans, Jr., S. S. Kirkpatrick and D. Y. Graham, 10:15-2G.
"Bacterium Causes Most Peptic Ulcers", Jerry E. Bishop, The Wall Street Journal, Feb. 10, 1994.
Chek-Med Systems, Inc.
Chovanes Eugene
Mohamed Abdel A.
Wityshyn Michael G.
LandOfFree
Test composition for the rapid detection of helicobacter pylori does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Test composition for the rapid detection of helicobacter pylori , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Test composition for the rapid detection of helicobacter pylori will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-970571