Test composition, device and method for detecting bilirubin

Details Test composition, device and method for detecting bilirubin Test composition, device and method for detecting bilirubin

1975-10-02

1977-07-26

Wolk, Morris O.

Chemistry: physical processes

Physical processes

Crystallization

23253TP, 252408, G01N 2106, G01N 3316

Patent

active

040380319

ABSTRACT:
A test composition, device, and method for detecting bilirubin in urine. The test composition includes a diazonium compound reactable with urinary bilirubin to produce a color change, an acid pH producing constituent, and a potentiating agent for the test reaction. The potentiating agent is an adduct of a ureido compound and an organic sulfonic acid or a salt form thereof. Particularly useful as the ureido constituent of the adduct are urea and substituted and unsubstituted cyclic ureido compounds, particularly those belonging to the xanthine family. The test device comprises a carrier, such as an absorbent matrix, incorporated with the test composition. The test method is carried out by contacting a urine test sample with the test composition and observing any resulting colorimetric response.

REFERENCES:
patent: 2854317 (1958-09-01), Free et al.
patent: 3526479 (1970-09-01), Rey et al.
patent: 3585001 (1971-06-01), Mast
Chem. Abstr., v. 19:14525, (1925).
Quigley, Anal. Chem., v. 24, pp. 1859-1860, (1952).
Merck Index, 8th Ed., pp. 188, 401 relied upon, (1968).

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