Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Calorimeter
Patent
1991-12-12
1992-12-22
Housel, James C.
Chemical apparatus and process disinfecting, deodorizing, preser
Analyzer, structured indicator, or manipulative laboratory...
Calorimeter
435970, 435805, 422 56, 422 681, 436170, 436524, G01N 3352
Patent
active
051732610
DESCRIPTION:
BRIEF SUMMARY
The invention relates to a test carrier for the analysis of fluids with a test field held in a frame, in which the frame comprises a top part and a base part and at least the top part comprises a test field opening through which a fluid sample can be applied to the surface of the test field.
For the qualitative or quantitative analytical determination of constituents of fluids, in particular body fluids of humans or animals, so-called carrier-bound test are increasingly being used. In the latter, reagents are embedded in the test layers of an analysis element designated overall as a test carrier. They are brought into contact with the sample. The reaction of sample and reagents leads to a detectable signal, in particular a colour change, which can be evaluated visually or by means of an apparatus, in most cases reflection-photometrically. Many different types of test carrier are known, which differ from one another not only with respect to the reagents used, but also in their construction, in particular as regards the arrangement and fixing of the test layers. The following type is of particular practical importance.
Strip-type test carriers consist mainly of an elongated carrying layer of plastics material and test layers attached thereto. The connection between the test layers and the plastics carrier is usually made by bonding, and the bonding in many cases does not take place over the whole surface, but only on one edge of the test layer, or additional fixing means (nets or fixing foils) are fixed to the carrying layer, which secure the test layers indirectly. In this way a very varied arrangement of the test layers next to one another and/or on one another, according to the requirements of the individual test, is possible. The test layers can be manufactured independently of one another and be joined together during the final assembly of the strip-type test carrier.
The invention is directed towards the type of test carrier mentioned at the outset, in which a test field is held by a frame similarly to a photographic slide. They are referred to below as "test carriers with frames" and in the English-language literature as "analysis slides". The sample is in this case usually applied through the test field opening onto one side (top side) of the test field. On the conclusion of the test reaction the colour formation can be observed or measured, usually on the side of the test field facing away from the sample side (bottom side of the test field).
The aim of the invention is to provide a test carrier with frame which is distinguished by simplified handling and improved analytical reliability.
The aim is achieved in the case of a test carrier of the kind described at the outset by the fact that the base part comprises a seat for the test field, the seat in the base part is surrounded by positioning means for the test field, the test field opening is greater than the test field, so that the rim of the test field is visible, and the top part comprises pressure tongues resting on the top surface the test field and projecting into the test field opening.
In the case of the previously known test carriers with frame the test field opening through which the blood sample is applied (blood application opening) was always smaller than the test field. The top part of the frame rested with a peripheral pressure face against the rim of the test field. Said arrangement was regarded as necessary in order to achieve adequate positioning and flatness of the test field. In addition it was assumed that only with a test field opening which covered the rim of the test field lateral flowing by of the blood could be prevented.
Here the invention demonstrates a radically different method, which proves to be exceptionally advantageous.
The top side of the test field can be seen in almost its entirety. In this way it becomes possible to inspect visually whether a sufficient amount of fluid sample has been applied and whether the test field is completely wetted. During the analysis of blood, in particular, incomplete wetting may be
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patent: 4181500 (1980-01-01), Cowsar et al.
patent: 4254083 (1981-03-01), Dolumbus
patent: 5006464 (1991-04-01), Chu et al.
patent: 5071746 (1991-12-01), Wilk et al.
patent: 5073340 (1991-12-01), Covington et al.
patent: 5104619 (1992-04-01), De Castro et al.
patent: 5106758 (1992-04-01), Adler et al.
Krause Manfred
Schindler Gerhard
Boehringer Mannheim GmbH
Housel James C.
Torres Ramon
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