Test article and method for performing blood coagulation assays

Details Test article and method for performing blood coagulation assays Test article and method for performing blood coagulation assays

1994-02-09

1995-05-23

Beisner, William H.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving blood clotting factor

435180, 436 69, 422 60, 530381, C12Q 156, C12N 1108, G01N 3386

Patent

active

054181437

ABSTRACT:
A test article for determining coagulation capability in a blood sample comprises a porous membrane having a coagulation initiator and substrate impregnated therein. The pore dimensions and composition of the membrane are selected so that only blood plasma can pass into the interior of the membrane, where coagulation is initiated. The substrate is activated by a component of the coagulation pathway, typically thrombin, and produces a detectable signal upon activation. By utilizing membrane matrix materials which are substantially free from interference with the coagulation pathway, accurate results can be achieved.

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Janson et al., "Species Specificity of Tissue Thromboplastin", Research Institute for Internal Medicine, University of Oslo, and the Animal Department, Rikshospitalet, 14:440-444 (1984).

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