Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals – Carrier is organic
Patent
1991-11-22
1994-01-25
Johnston, Jill A.
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
Carrier is organic
422 56, 422 57, 422 58, 436531, G01N 33545, G01N 33544
Patent
active
052815404
ABSTRACT:
A semi-automated biological sample analyzer and subsystems are provided to simultaneously perform a plurality of enzyme immunoassays for human IgE class antibodies specific to a panel of preselected allergens in each of a plurality of biological samples. A carousel is provided to position and hold a plurality of reaction cartridges. Each reaction cartridge includes a plurality of isolated test sites formed in a two dimensional array in a solid phase binding layer contained within a reaction well which is adapted to contain a biological sample to be assayed. The carousel and cartridges contain structures which cooperate to precisely position the cartridges in each of three separate dimensions so that each cartridge is positioned uniformly. An optical reader operating on a principle of diffuse reflectance is provided to read the results of the assays from each test site of each cartridge. Also provided is a subsystem which provides predetermined lot-specific assay calibration data which is useful for normalizing the results of various assays with respect to predetermined common standard values.
REFERENCES:
patent: 4301115 (1981-11-01), Rapkin et al.
patent: 4776904 (1988-10-01), Charlton et al.
patent: 4797259 (1989-01-01), Matkovich et al.
patent: 5075077 (1991-12-01), Durley, III et al.
Defreese James D.
Durley, III, deceased Benton A.
Merkh Carl W.
Abbott Laboratories
Johnston Jill A.
Pope Lawrence S.
Ungemach Frank s.
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