Tertiary 2,5-dialkyl-3-phenylpiperidine derivatives having opiat

Details Tertiary 2,5-dialkyl-3-phenylpiperidine derivatives having opiat Tertiary 2,5-dialkyl-3-phenylpiperidine derivatives having opiat

1990-05-29

1992-02-25

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514331, 546237, 546240, 546192, 546230, 546233, 546234, 546235, A61K 31445, C07D21120

Patent

active

050913930

ABSTRACT:
The invention relates to a group of tertiary 2,5-dialkyl-3-phenylpiperidine derivatives, having opiate-antagonistic activity represented by general formula 4, ##STR1## wherein A.sub.1 is hydrogen, an optionally esterified hydroxyl group or mercapto group, a group NHA.sub.8 or --CONHA.sub.8, wherein A.sub.8 is hydrogen, alkyl having 1-6 C-atoms or alkylcarbonyl having 2-7 C-atoms;

REFERENCES:
patent: 4081450 (1978-03-01), Zimmerman
patent: 4284635 (1981-08-01), Zimmerman
patent: 4593037 (1986-06-01), Sarges
Chemical Abstracts, 74:22700h (1971), "Butyrophenone Derivatives."
M. Iorio et al., J. Med. Chem., 21(8), "Nalorphine-like properties of some 2,3-dimethyl-3-arylpiperdines (1978)".

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