Terphenyl derivatives, preparation thereof, compositions...

Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing

Reexamination Certificate

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Reexamination Certificate

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07390924

ABSTRACT:
The invention relates to terphenyl derivatives of formula:and to their preparation and to the pharmaceutical compositions comprising them.These compounds exhibit an antagonist activity with respect to CB1cannabinoid receptors.

REFERENCES:
patent: 4916145 (1990-04-01), Tilley et al.
patent: 2800375 (2001-05-01), None
Bass et al., SR-141716A-induced stimulation of locomotor activity. A structure-activity relationship study. Pharmacology, Biochemistry & Behavior, 74 (2002) 31-40.
Brenna, B., et. al., New Route to O-Terphenyls: Application to the Synthesis of 6,7,10,11-Tetramethoxy-2-(Methoxycarbonyl)Triphenylene, J. Chem. Soc. Perkins Trans. 1, (1998) pp. 901-904.
Rinaldi-Carmona, M., et. al., SR141716A, A Potent and Selective Antogonist of the Brain Cannabinoid Receptor, Febs Letters, Elsevier Science Publishers, Amsterdam, NL, vol. 350, No. 2/3, (1994) pp. 240-244.
Sato, et. al., A New Route to Polycondensed Aromatics: Photolytic Formation of Triphenylene and Dibenzo[f,g, op]Naphthacene Ring Systems, Bulletin of The Chemical Society of Japan, vol. 44, pp. 2484-2490 (1971).

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