Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound
Patent
1995-04-03
1998-04-28
Kight, John
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
In an organic compound
424 165, 534 10, 534 14, 530317, 514 9, 514 11, A61K 5100, A61M 3614
Patent
active
057441200
ABSTRACT:
This invention provides novel radiopharmaceuticals which are useful as imaging agents for the diagnosis of cardiovascular disorders, infectious disease and cancer. The radiopharmaceuticals are comprised of phosphine or arsine ligated technetium-99m labeled hydrazino or diazino modified biologically active molecules that selectively localize at sites of disease and thus allow an image to be obtained of the loci using gamma scintigraphy. This invention also provides methods for using the radiopharmaceuticals and kits comprising radiopharmaceutical precursors. The radiopharmaceuticals of this invention have the structure: (A.sub.L2).sub.z ;
wherein the variables are as defined herein.
REFERENCES:
patent: 4917879 (1990-04-01), Deutsch et al.
patent: 4957728 (1990-09-01), Deutsch et al.
patent: 5045302 (1991-09-01), Kelly et al.
patent: 5066789 (1991-11-01), Srinivasan et al.
patent: 5112594 (1992-05-01), Woulfe et al.
patent: 5300278 (1994-04-01), Pasqualini et al.
patent: 5336482 (1994-08-01), Edwards et al.
patent: 5350837 (1994-09-01), Bridger et al.
patent: 5384309 (1995-01-01), Barker et al.
patent: 5493007 (1996-02-01), Burnier et al.
patent: 5521156 (1996-05-01), Owen et al.
Liu et al (1996), Bioconjugate Chem., vol. 7, No. 1, pp. 63-71, Labeling a Hydrazino Nicotinamide Modified Cyclic IIb/IIIa Receptor Antagonist with 99m-TC Using Aminocarboxylates as Coligards.
Pearson et al (1996), J. Med. Chem., vol. 39, No. 7, pp. 1372-1382, "Thrombus Imaging Using Technetium-99m Labeled High Potency GPIIb/IIIa Receptor Antagonists, Chemistry and Biological Studies."
Pasqualini, et al., J. Chem. Soc. Dalton Trans., 3729-3733 (1990).
Pasqualini, et al., Appl. Radiat. Isot., 43, No. 2, 425-436 (1992).
Edwards David Scott
Liu Shuang
Boudreaux Gerald J.
Jones Dameron
Kight John
The DuPont Merick Pharmaceutical Company
Vance David H.
LandOfFree
Ternary radiopharmaceutical complexes does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Ternary radiopharmaceutical complexes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ternary radiopharmaceutical complexes will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1529736