Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound
Patent
1997-02-28
1999-03-09
Dees, Jose' G.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
In an organic compound
424 165, 534 10, 534 14, 530317, 514 9, 514 11, A61K 5100, A61K 3812, A61M 3614, C07F 500
Patent
active
058796592
ABSTRACT:
This invention relates to novel radiopharmaceuticals which are useful as imaging agents for the diagnosis of cardiovascular disorders, infectious disease and cancer, and to kits useful for their preparation. The radiopharmaceuticals of this invention are comprised of a transition metal radionuclide, a transition metal chelator, a biologically active group connected to said chelator, a first ancillary ligand, a second ancillary ligand capable of stabilizing the radiopharmaceutical, optionally having a linking group between said chelator and said biologically active group. Preferred radiopharmaceuticals of this invention have the formula: (A.sub.L2).sub.z,
wherein the shown variables are as defined herein.
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Edwards David Scott
Liu Shuang
Boudreaux G. Jess
Dees Jos,e G.
DuPont Pharmaceuticals Company
Hartley Michael G.
Vance David H.
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