Imperforate bowl: centrifugal separators – Process
Patent
1993-04-02
1994-12-06
Scherbel, David A.
Imperforate bowl: centrifugal separators
Process
494 7, 494 10, 494 11, 364502, B04B 1300
Patent
active
053705998
ABSTRACT:
A method of controlled centrifugation including automatic determination (before or during a centrifugation run) of the time to reach "completion" (within specified limits, depending on the criteria adopted) of a centrifugal separation. By simulation, the sample solute concentration distributions are determined and examined periodically. Centrifugation completion is deemed to have been reached based on certain predetermined criteria relating to spatial changes in the sample solute concentration distributions between successive examinations. The positions of the end points of the concentration distributions or band edges of the sample solutes (transitions from regions of sample solutes to regions of no sample solutes) are determined to facilitate resolving spatial changes of the concentration distributions. The position of an end point or band edge is characterized by a specific location along the centrifuge tube where an imaginary boundary exists at which no more than a specific % of the total mass of the solute in the band lies outside said boundary. In order to avoid premature termination of centrifugation before actual equilibrium has been reached as a result of excessive frequent checks of the motion of the concentration distribution because of relatively long time scale in sedimentation, an estimate is provided of a characteristic periodic interval between successive checks of sample solute concentration distributions.
REFERENCES:
patent: 3009388 (1961-11-01), Polanyi
patent: 4244513 (1981-01-01), Fayer et al.
patent: 4285810 (1981-08-01), Kirkland et al.
patent: 4941868 (1990-07-01), Chulay et al.
patent: 5171206 (1992-12-01), Marque
Publication entitled "Computer Derived Rotor Speed Protocols for in situ Control of Local Solute Concentration during Centrifugation", Proceedings of the 112th Annual Meeting of the American Society of Mechanical Engineers, BED-vol 21, Bioprocess Engineering Symposium, Book No. H00726-1991, pp. 9-13, 1991.
Marque Jeffrey J.
Minton Allen P.
Voelker Paul J.
Beckman Instruments Inc.
Cooley Charles
Hampson Gary T.
Harder P. R.
May William H.
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