Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Patent
1997-10-23
1999-07-13
Dees, Jose G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
544364, 544336, 544358, 544359, 514255, C07D41300, C07D40100, A61K 31495
Patent
active
059228717
ABSTRACT:
The present invention relates to novel terephthalamide derivatives and in particular to novel terephthalamide derivatives of the following formula 1, its pharmaceutically acceptable salts as antiviral agents having remarkable inhibitory actions against the proliferation of various viruses including HIV and HBV, and preparing method thereof ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are the same as defined in the detailed description of the present invention.
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patent: 5563142 (1996-10-01), Palmer et al.
patent: 5599930 (1997-02-01), Romero et al.
Romero, D.L., "Nonnucleoside reverse transcriptase inhibitors that potently and specifically block human immunodeficiency virus type 1 replication," Proc. Natl. Acad. Sci. USA, vol. 88, pp. 8806-8810, Oct. 1991.
Beach, et al., "Synthesis of Enantiomerically Pure Antiviral Agent Against Hepatitis B Virus (HBV) and Human Immunodeficiency Virus (HIV)," Journal of Organic Chemistry,, vol. 57, No. 8 (1992), pp. 2217-2219.
Romero, et al., "Discovery, Synthesis, and Bioactivity of Bis(Heteroaryl)Piperazines. 1. A Novel Class of Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors," Journal of Medicinal Chemistry, vol. 37, No. 7 (1994), pp. 999-1014.
Chung Yong Ho
Huh Yong
Kim Jong Woo
Lee Sang Wook
Park Sang Jin
Dees Jos,e G.
Dongwha Pharmaceutical Ind. Co., Ltd.
Qazi Sabiha N.
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