Terbenzimidazoles useful as antifungal agents

Details Terbenzimidazoles useful as antifungal agents Terbenzimidazoles useful as antifungal agents

1997-01-21

1998-06-23

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5483054, A61K 31415

Patent

active

057706174

ABSTRACT:
The present invention provides a method of treatment of fungal infection with an antifungal topoisomerase I inhibitor of the formula: ##STR1## wherein Ar is (C.sub.6 -C.sub.12)aryl, a (5- to 12-membered) heteroaryl comprising 1-3 N, S or non-peroxide O, wherein N is unsubstituted or is substituted with H, (C.sub.1 -C.sub.4)alkyl or benzyl; or benzo; X is H, CN, CHO, OH, acetyl, CF.sub.3, O(C.sub.1 -C.sub.4)alkyl, NO.sub.2, NH.sub.2, halogen or halo-(C.sub.1 -C.sub.4)alkyl; each Y is individually H, (C.sub.1 -C.sub.4)alkyl or aralkyl; Y' is H or (C.sub.1 -C.sub.4)alkyl; n is 0 or 1; and each Z is individually H, (C.sub.1 -C.sub.4)alkyl, halogen or halo(C.sub.1 -C.sub.4)alkyl; or a pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 5639755 (1997-06-01), Dykstra et al.
patent: 5643935 (1997-07-01), Dykstra et al.

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