Ten-membered ring enediynediols and enediynediones having DNA cl

Details Ten-membered ring enediynediols and enediynediones having DNA cl Ten-membered ring enediynediols and enediynediones having DNA cl

1991-11-05

1993-02-02

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568821, 568561, 568327, 568326, 568808, 424422, 549505, 549229, C07C 49105, C07C 3520

Patent

active

051839423

ABSTRACT:
Macrocyclic enediynediols and enediynediones having a ten carbon ring and open chain enediyne dihydroperoxides having eight carbons between the hydroperoxide groups that cleave DNA are disclosed, as are methods of making and using the same.

REFERENCES:
Darby, N. et al. J. Chem. Soc. D(23) 1516-1517 1971.

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