Temporary living skin replacement

Details Temporary living skin replacement Temporary living skin replacement

1994-02-18

1995-10-24

Wityshyn, Michael G.

Chemistry: molecular biology and microbiology

Differentiated tissue or organ other than blood, per se, or...

4352401, 43524023, 424572, 424574, 424 931, 424 9321, 424 937, C12N 1100, A61F 210, C12M 300

Patent

active

054609399

ABSTRACT:
The present invention relates to a living skin replacement. In particular, it relates to a biosynthetic dressing material composed of a living stromal tissue prepared from stromal cells such as fibroblasts cultured upon a three-dimensional framework and a transitional covering which acts as an epidermal replacement. Such a living skin replacement provides long-term biologic coverage of full-thickness wound defects. Since human fibroblasts are known to be relatively non-antigenic when transferred to allogeneic hosts, a temporary living skin replacement made up of such cells attached to a transitional covering may replace the use of cadaveric skin allografts for achieving temporary wound closure in cases where the patients lack enough healthy skin for autografts.

REFERENCES:
Hansbraugh, et al. 1993 Proc of the ABA 29th Annual Mtg. Mar. 24-27 Cincinnati, Ohio vol. 25.
Woodroof, "Biobrane A Biosynthetic Skin Prosthesis," from Burn Wound Coverings, published by CRC Press, Inc. ed. D. L. Wise Ph.D., in press, pp. 1-20 (No Pub. Date).
Hansbrough et al., 1993, "Evaluation of living biosynthetic temporary skin replacement: Human fibroblasts cultured on biobrane," Proceedings of the ABA Twenty-Fifth Annual Meeting Mar. 24-27, Cincinnati, Ohio, vol. 25.
Purdue et al., 1987, "Biosynthetic skin substitute versus frozen human cadaver allograft for temporary coverage of excised burn wounds," J. Trauma 27:155-157.
McHugh et al., 1986, "Therapeutic efficacy of biobrane in partial and full-thickness thermal injury," Surgery 100:661-664.
Frank and Bonaldi, 1985, "Inhibition of wound contraction: Comparison of full-thickness skin grafts, biobrane, and aspartate membranes," Annals of Plastic Surgery 14:103-110.
Zapata-Sirvent et al., 1985, "Comparison of biobrane and scarlet red dressings for treatment of donor site wounds," Archives of Surgery 120:743-745.
Hansbrough et al., 1984, "Clinical experience with biobrane biosynthetic dressing in the treatment of partial thickness burns," Burns 10:415-419.
Frank et al., 1983, "Comparison of biobrane, porcine, and human allograft as biologic dressings for burn wounds," J. Burn Care Rehab., 4:186-190.
Lin et al., 1982, "A comparison of IP-758 and biobrane in rats as temporary protective dressings on widely expanded meshed autografts," J. Burn Care Rehab. 3:220-222.
Zachary et al., 1982, "The use of topical antimicrobials combined with biobrane in burn wound infections," J. Trauma 22:833-836.
Bartlett, 1981, "Skin substitutes," J. Trauma 21:731-732.
Tavis et al., 1976, "Graft adherence to de-epithelialized surfaces: A comparative study," Annals of Surgery 184:594-600.

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