Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1994-01-14
1997-08-19
Ketter, James S.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
4352872, C12Q 168, C12M 100
Patent
active
056587287
ABSTRACT:
Templates for the binding and synthesis of biological molecules are disclosed. The templates according to the invention consist of an atomically flat substrate and a three-dimensional pattern formed on the substrate by the positioning of individual atoms or molecules or groups of atoms or molecules to form hillocks. The hillocks are capable of binding to complementary portions of biological molecules or their component molecules.
REFERENCES:
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4683202 (1987-07-01), Mullis
patent: 4728591 (1988-03-01), Clark et al.
patent: 4941753 (1990-07-01), Wickramasinghe
patent: 5038322 (1991-08-01), Van Loenen
patent: 5143854 (1992-09-01), Pirrung et al.
patent: 5307311 (1994-04-01), Sliwa, Jr.
March, Advanced Organic Chemistry:Reactions, Mechanisms and Structure, 1968, McGraw-Hill, New York, pp. 63-65.
Fodor, et al., "Light-directed, spatially addressable parallel chemical synthesis," Science 251:767-773 (1991).
McCormick, et al., "A scanning tunneling microscope for biophysical research," Biophysical Journal 57:383a (1990).
Blankenship, Bill, "Moving Atoms," Think 3:32-33 (1990).
Driscoll, et al., "Atomic-scale imaging of DNA using scanning tunnelling microscopy," Nature 346:294-296 (1990).
Dunlap, et al., "Images of single-stranded nucleic acids by scanning tunnelling microscope," Nature 342:204-206 (1989).
Barris, et al., "Images of DNA fragments in an aqueous environment by scanning tunneling microscopy," Biopolymers 27:1691-1696 (1988).
Foster, et al., "Molecular manipulation using a tunnelling microscope," Nature 331:324-326 (1988).
Hansma, et al., "Scanning tunneling microscopy and atomic force microscopy: application to biology and technology," Science 242:209-216 (1988).
Lindsay, et al., "Can the scanning tunneling microscopy sequence DNA?", Genetic Analysis, Techniques, and Applications 8:8-13 (1991).
Lindsay, et al., "Adsorbate deformation as a contrast mechanism in STM images of biopolymers in an aqueous environment: images of the unstained, hydrated DNA double helix," Journal of Microscopy 152:213-220 (1988).
Lindsay, et al., "Imaging deoxyribose nucleic acid molecules on a metal surface under water by scanning tunneling microscopy," J Vac Sci Technol 6:544-547 (1988).
Schneir, et al., "Tunneling microscopy, lithography, and surface diffusion on an easily prepared, atomically flat gold surface," Journal of Applied Physics 63:717-721 (1988).
Becker, et al., "Atomic-scale surface modifications using a tunnelling microscope," Nature 325:419-421 (1987).
Binnig, G., "Paradox in practice: the scanning tunnelling microscope and its applications," Speculations in Science & Technology 10:345-352 (1987).
Morawitz, et al., "Multiple image potential effects in a simple model of the scanning tunnelling microscope (STM)," Surface Science 180:333-352 (1987).
Silver, et al., "Direct writing of submicron metallic features with a scanning tunneling microscope," Appl Phys Lett 51:247-249 (1987).
Staufer, et al., "Nanometer scale structure fabrication with the scanning tunneling microscope," Appl Phys Lett 51;244-246 (1987).
Abraham, et al., "Surface Modification with the Scanning tunneling microscope," IBM J Res Develop 30:492-499 (1986).
Gomer, R., "Possible mechanisms of atom transfer in scanning tunneling microscopy," IBM J Res Develop 30:428-430 (1986).
West, et al., "Chemical applications of scanning tunneling microscopy," IBM J Res Develop 30:484-491 (1986).
Pashley, et al., "Scanning tunnelling microscope studies," Surface Science 152/153:27-32 (1985) Amsterdam, Netherlands.
"Lawrence Berkeley-Livermore team obtains first direct images of DNA," Genetic Engineering News, p. 3 (Mar., 1989).
Yau, et al., "Nanofabrication with a scanning tunneling microscope," J. Appl Phys 69:2970-2974 (1991).
Stroscio, et al., "Atomic and molecular manipulation with the scanning tunneling microscope," Science 254:1819-1826 (1991).
Whiteman, et al., "Manipulation of adsorbed atoms and creation of new structures on room-temperature surfaces with a scanning tunneling microscope," Science 251:1206-1210 (1991).
Lyo, et al., "Field-induced nanometer-to atomic-scale manipulation of silicon surfaces with the STM," Science 253:173-176 (1991).
Harbers, et al. "Chemistry of the nucleic acids," Introduction to Nucleic Acids. Chemistry, Biochemistry and Functions, Reinhold Bood Corp., New York, pp. 32-57 (1968).
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