Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Scleroproteins – e.g. – fibroin – elastin – silk – etc.
Reexamination Certificate
2003-10-31
2009-08-11
Desai, Anand U (Department: 1656)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Scleroproteins, e.g., fibroin, elastin, silk, etc.
C436S177000
Reexamination Certificate
active
07572894
ABSTRACT:
One aspect of the present invention relates to a method of preparing a fibrous protein smectic hydrogel by way of a solvent templating process, comprising the steps of pouring an aqueous fibrous protein solution into a container comprising a solvent that is not miscible with water; sealing the container and allowing it to age at about room temperature; and collecting the resulting fibrous protein smectic hydrogel and allowing it to dry. Another aspect of the present invention relates to a method of obtaining predominantly one enantiomer from a racemic mixture, comprising the steps of pouring an aqueous fibrous protein solution into a container comprising a solvent that is not miscible with water; sealing the container and allowing it to age at about room temperature; allowing the enantiomers of racemic mixture to diffuse selectively into the smectic hydrogel in solution; removing the smectic hydrogel from the solution; rinsing predominantly one enantiomer from the surface of the smectic hydrogel; and extracting predominantly one enantiomer from the interior of the smectic hydrogel. The present invention also relates to a smectic hydrogel prepared according to an aforementioned method.
REFERENCES:
Hukins, D. W. L. et al., “Collagen Fibrils as Examples of Smectic A Biological Fibres”,Mol. Cryst. Liq. Cryst., 41(2):33-40 (Gordon and Breach Science Publishers, Ltd., USA) (1977).
Valluzzi, R. et al., “Bombyx morisilk fibroin liquid crystallinity and crystallization at aqueous fibroin-organic solvent interfaces”,Intern. J. of Biol. Macromol., 24:227-236 (Elsevier Science B.V.)(Mar. 1999).
Ayub, Z. H. et al., “Mechanism of the Gelation of Fibroin Solution”,Biosci. Biotech. Biochem., 57(11):1910-1912 (May 24, 1993).
Bunnak, J. et al., “Study on Antibacterial Activity of Hydrogel from Irradiated Silk Protein”,JAERI Conf., 117-129 (2001) (Abstract).
Dinerman, A. A. et al., “Swelling behavior of a genetically engineered silk-elastinlike protein polymer hydrogel”,Biomaterials, 23:4203-4210 (2002).
Jin, H.-J. et al., “Biomaterial Films ofBombyx moriSilk Fibroin with Poly(ethylene oxide)”,Biomacromolecules, 5:711-717 (2004).
Zhang, Y.-Q., “Applications of natural silk protein sericin in biomaterials”,Biotechnology Advances, 20:91-100 (2002).
International Search Report dated Jul. 2, 2004.
Jin Hyoung-Joon
Park Jae-Hyung
Valluzzi Regina
Desai Anand U
Foley & Hoag LLP
Gordon Dana M.
Trustees of Tufts College
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