Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2002-06-20
2010-06-01
Riley, Jezia (Department: 1637)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S005000, C435S007100, C435S007200, C435S091100, C536S022100, C536S023100, C536S025300, C530S300000, C530S350000
Reexamination Certificate
active
07727713
ABSTRACT:
The present invention relates to a method for synthesizing templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The intion allows the generation of libraries which can be screened for e.g. therapeutic activity.
REFERENCES:
patent: 4822731 (1989-04-01), Watson et al.
patent: 5047519 (1991-09-01), Hobbs, Jr. et al.
patent: 5476930 (1995-12-01), Getsinger et al.
patent: 5503805 (1996-04-01), Sugarman et al.
patent: 5571903 (1996-11-01), Gryaznov
patent: 5573905 (1996-11-01), Lerner et al.
patent: 5639603 (1997-06-01), Dower et al.
patent: 5665975 (1997-09-01), Kedar et al.
patent: 5681943 (1997-10-01), Letsinger et al.
patent: 5708153 (1998-01-01), Dower et al.
patent: 5723598 (1998-03-01), Lerner et al.
patent: 5741643 (1998-04-01), Gryaznov et al.
patent: 5770358 (1998-06-01), Dower et al.
patent: 5780613 (1998-07-01), Letsinger et al.
patent: 5789162 (1998-08-01), Dower et al.
patent: 5830658 (1998-11-01), Gryaznov et al.
patent: 5843650 (1998-12-01), Segev
patent: 5948648 (1999-09-01), Khan et al.
patent: 6056926 (2000-05-01), Sugarman et al.
patent: 6060596 (2000-05-01), Lerner et al.
patent: 6096875 (2000-08-01), Khan et al.
patent: 6140493 (2000-10-01), Dower et al.
patent: 6143497 (2000-11-01), Dower et al.
patent: 6143503 (2000-11-01), Baskerville et al.
patent: 6165717 (2000-12-01), Dower et al.
patent: 6165778 (2000-12-01), Kedar et al.
patent: 6197555 (2001-03-01), Khan et al.
patent: 6207446 (2001-03-01), Szostak et al.
patent: 6248568 (2001-06-01), Khan et al.
patent: 6297053 (2001-10-01), Stemmer
patent: 6416949 (2002-07-01), Dower et al.
patent: 6429300 (2002-08-01), Kurz et al.
patent: 6593088 (2003-07-01), Saito et al.
patent: 6620587 (2003-09-01), Taussig et al.
patent: 2003/0004122 (2003-01-01), Beigelman et al.
patent: 2003/0113738 (2003-06-01), Liu et al.
patent: 2005/0025766 (2005-02-01), Liu
patent: 2005/0042669 (2005-02-01), Liu
patent: 196 46 372 (1997-06-01), None
patent: 0324616 (1989-07-01), None
patent: 0 643 778 (1993-10-01), None
patent: 0604552 (1994-07-01), None
patent: 0695305 (1994-10-01), None
patent: 0830363 (1996-11-01), None
patent: 0773227 (1997-05-01), None
patent: 0776330 (1997-06-01), None
patent: 1533385 (2005-05-01), None
patent: 9005785 (1990-05-01), None
patent: 9105058 (1991-04-01), None
patent: WO 93/03172 (1993-02-01), None
patent: WO 93/06121 (1993-04-01), None
patent: 9512608 (1995-05-01), None
patent: 9609316 (1996-03-01), None
patent: 9612014 (1996-04-01), None
patent: 9831700 (1998-07-01), None
patent: WO 98/56904 (1998-12-01), None
patent: 0021909 (2000-04-01), None
patent: 0023458 (2000-04-01), None
patent: WO 00/23458 (2000-04-01), None
patent: 0032823 (2000-06-01), None
patent: 0047775 (2000-08-01), None
patent: WO 00/61775 (2000-10-01), None
patent: WO 00/61775 (2000-10-01), None
patent: WO 01/00876 (2001-01-01), None
patent: WO 02/074929 (2002-09-01), None
patent: 02102820 (2002-12-01), None
patent: 03078050 (2003-09-01), None
patent: 03078445 (2003-09-01), None
patent: 03078446 (2003-09-01), None
patent: 03078625 (2003-09-01), None
patent: 03078626 (2003-09-01), None
patent: 03082901 (2003-10-01), None
patent: 2004001042 (2003-12-01), None
patent: 2004009814 (2004-01-01), None
patent: 2004013070 (2004-02-01), None
patent: 2004016767 (2004-02-01), None
patent: 2004024929 (2004-03-01), None
patent: 2004039825 (2004-05-01), None
patent: 2004056994 (2004-07-01), None
patent: 2004074429 (2004-09-01), None
patent: 2004074501 (2004-09-01), None
patent: 2004083427 (2004-09-01), None
patent: 2004099441 (2004-11-01), None
patent: 2004110964 (2004-12-01), None
patent: 2005003778 (2005-01-01), None
patent: 2005026387 (2005-03-01), None
Nemoto, N et al. “In vitro virus: bonding of mRNA bearing puromycin at the 3′-terminal end to the C-terminal end of its encoded protein on the ribosome in vitro”. FEBS Lett. Sep. 8, 1997;414(2):405-8.
Roberts, RW et al. “RNA-peptide fusions for the in vitro selection of peptides and proteins”. Proc Natl Acad Sci U S A. Nov. 11, 1997;94(23):12297-302.
Kurz, M et al. “An efficient synthetic strategy for the preparation of nucleic acid-encoded peptide and protein libraries for in vitro evolution protocols” Fourth International Electronic Conference on Synthetic Organic Chemisty (ECSOC-4), www.mdpi.org/ecsoc-4.htm. Sep. 1-30, 2000.
Kurz, M et al. Psoralen phot-crosslinked mRNA-puromycin conjugates: a novel template for the rapid and facile preparation of mRNA-protein fusions. Nucleic Acids Res. Sep. 15, 2000;28(18):E83.
Benner, SA. “Expanding the genetic lexicon: incorporating non-standard amino acids into proteins by ribosome-based synthesis”. Trends Biotechnol. May 1994;12(5):158-63.
Mendel, D.“Site-directed mutagenesis with an expanded genetic code”. Annu. Rev. Biophys. Biomol. Struc. 1995. 24:435-62.
Liu DR et al. “Engineering a tRNA and aminoacyl-tRNA synthetase for the site-specific incorporation of unnatural amino acids into proteins in vivo”. Proc Natl Acad Sci U S A. Sep. 16, 1997;94(19):10092-7.
Liu DR et al. “Progress toward the evolution of an organism with an expanded genetic code”. Proc Natl Acad Sci USA. Apr. 27, 1999;96(9):4780-5.
Liu, R et al. “Optimized synthesis of RNA-protein fusions for in vitro protein selection”. Methods Enzymol. 2000;318;268-93.
Wang, L et al. “A new functional suppressor tRNA/aminoacyl-tRNA synthetase pair for the in vivo incorporation of unnatural amino acids into proteins” J. Am. Chem. Soc 2000, 122, 5010-5011 Pub Apr. 5, 2000.
Eilman J.A., et al. “Biosynthetic method for introducing Unnatural Amino acids site specifically into proteins”. Methods Enzymol. 2002. 301-336 (1992).
Dower, WJ et al. “In vitro selection as a powerful tool for the applied evolution of proteins and peptides”.Current Opinion in Chemical Biology, 2002, 6:390-398.
Gartner, ZJ et al. “Multistep small-molecule synthesis programmed by DNA templates”. J. Am. Chem. Soc. vol. 124, No. 35, 2002, 10304-10306.
Calderone, CT et al. “Directing otherwise incompatible reactions in a single solution by using DNA-templated organic synthesis”. Angew Chem Int Ed, 2002, 41, No. 21. 4104-4108.
Gartner, ZJ et al. “Two enabling architectures for DNA-templated organic synthesis”. Angew. Chem Int. Ed. 2003, 42, No. 12, 1370-1375.
Rosenbaum, DM et al. “Efficient and sequence-specific DNA-templated polymerization of peptide nucleic acid aldehydes”. J. Am. Chem. Soc. vol. 125, No. 46, 2003, 13924-13925.
Li, X et al. “Stereoselectivity in DNA-templated organic synthesis and its origins”. J. Am. Chem. Soc. vol. 125, No. 34, 2003, 10188-10189.
Gordon, EM et al. “Applications of combinatorial technologies to drug discovery. 2. Combinatorial organic synthesis, library screening strategies, and future directions”. Journal of Medicinal Chemistry, vol. 37, No. 10, May 13, 1994.
Otto, S et al. S“Recent developments in dynamic combinatorial chemistry”. Current opinion in Chemical Biology 2002, 6: 321-327.
Pavia, MR. “The Chemical generation of molecular diversity”. http://www.netsci.org/Science/Combichem/feature01.html.
Braun, E, et al. “DNA-templated assembly and electrode attachment of a conducting silver wire”. Nature, vol. 391, Feb. 19, 1998, 775-778.
Tanaka, K et al. “Synthesis of a novel nucleoside for alternative DNA base pairing through metal complexation” J. Org. Chem. 1999, 64, 5002-5003.
Weizman, H et al. “2,2′-Bipyridine ligandoside: a novel building block for modifying DNA with intra-duplex metal complexes”. J. Am. Chem. Soc. 2001, 123, 3375-3376.
Frutos, AG et al. “Demonstration of a word design strategy for DNA computing on surfaces”. Nucleic Acids Research, 1997, vol. 25, No. 23, 4748-4757.
Loweth, CJ et al. “DNA-based assembly of gold nanocrystals”. Angew. Chem. Int. Ed. 19
Felding Jakob
Franch Thomas
Freskgård Per-Ola
Glad Sanne Schrøder
Godskesen Michael Anders
Cooper Iver P.
Nuevolution A/S
Riley Jezia
LandOfFree
Templated molecules and methods for using such molecules does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Templated molecules and methods for using such molecules, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Templated molecules and methods for using such molecules will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4234077