Template-fixed peptidomimetics with antimicrobial activity

Details Template-fixed peptidomimetics with antimicrobial activity Template-fixed peptidomimetics with antimicrobial activity

2002-10-02

2010-12-21

Kosar, Andrew D (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S327000, C530S333000

Reexamination Certificate

active

07855179

ABSTRACT:
Template-fixed β-hairpin peptidomimetics of the general formula (I), wherein Z is a template-fixed chain of 12 α-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly or Pro, or of certain types, at least one of these residues being of the type of N-substituted glycines, which types, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to inhibit the growth of or to kill microorganisms. They can be used as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials or as medicaments to treat or prevent infections. These β-hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy.

REFERENCES:
patent: WO 01/16161 (2001-03-01), None
patent: WO 02/70547 (2002-09-01), None
Zuckermann et al (Polymer Preprints 35(2) 1994 pp. 975-976).
Miller et al (Bioorganic and Medicinal Chemistry Letters v4 1994 pp. 2657-2662).
Goodson et al (Antimicrobial agents and chemotherapy v43 1999, pp. 1429-1434).
J. Rudinger. In: Peptide Hormones, JA Parsons, Ed. (1976) 1-7.

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