Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2003-05-02
2010-11-23
Kosar, Andrew D (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C530S326000, C530S327000
Reexamination Certificate
active
07838496
ABSTRACT:
Template-fixed β-hairpin peptidomimetics of the General Formula (I); wherein Z1and Z2are template-fixed chains of 4 and 6 or 5 and 7 α-amino acid residues and salts thereof. They have CXCR4-antagonizing properties and can be used as medicaments. These β-sheet peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.
REFERENCES:
patent: WO 01/16161 (2001-03-01), None
patent: WO 02/070547 (2002-09-01), None
patent: WO 03/054000 (2003-07-01), None
STN database (STN database entry for registry No. 493552-90-2 entered Feb. 21, 2003 2 pages).
J. Rudinger. In: Peptide Hormones, JA Parsons, Ed. (1976) 1-7.
Shankaramma et al.; Macrocyclic Hairpin Mimetics of the Cationic Antimicriobial Peptide Protegrin I: A New Family of Broad-Spectrum Antibiotics; ChemBioChem 2002, vol. 3, pp. 1126-1133.
Tamamura et al., Certification of the Critical Importance of L-3-(2-Naphthyl)alanine at Position 3 of a Specific CXCR4 Inhibitor, T140, Leads to an Exploratory Performance of Its Downsizing Study; Bioorganic & Medicinal Chemistry, vol. 10 (2002), pp. 1417-1426.
Robinson; The Design, Synthesis and Conformation of Some New β-Hairpin Mimetics: Novel Reagents for Drug and Vaccine Discovery; Synlett, 2000; No. 4, pp. 429-441.
Favre, et al.; Structural Mimicry of Canonical Conformations in Antibody Hypervariable Loops Using Cyclic Peptides Containing a Heterochiral Diproline Template; J. Am. Chem. Soc., 1999, vol. 121, pp. 2679-2685.
Fujii et al.; Peptide-lead CXCR4 antagonists with high anti-HIV activity; Current Opinion in Investigational Drugs; 2001 2(9); pp. 1198-1202.
Tamamura et al.; Development of Specific CXCR4 Inhibitors Possessing High Selectivity Indexes as Well as Complete Stability in Serum Based on an Anti-HIV Peptide T140; Bioorganic & Medicinal Chemistry Letters 11 (2001) 1897-1902.
Tamarura et al.; Conformational Study of a Highly Specific CXCR4 Inhibitor, T140, Disclosing the Close Proximity of Its Intrinsic Pharmacophores Associated with Strong Anti-HIV Activity; Bioorganic & Medicinal Chemistry Letters 11 (2001) 359-362.
Jiang et al.; Combinatorial Biomimetic Chemistry: Parallel Synthesis of a Small Library of β-Hairpin Mimetics Based on Loop III from Human Platelet-Derived Growth Factor B; Helvetica Chimica Acta; vol. 83, (2000) pp. 3097-3112.
Obrecht et al.; Novel Peptide Mimetic Building Blocks and Strategies for Efficient Lead Finding; Advances in Medicinal Chemistry; 1999; vol. 4, pp. 1-68.
Hanessian et al., Design and Synthesis of Conformationally Constrained Amino Acids as Versatile Scaffolds and Peptide Mimetics; Tetrahedron, vol. 53, No. 38; 1997; pp. 12789-12854.
Sato et al., Solid phase synthesis of human growth hormone-releasing factor analogs containing a bicyclic β-turn dipeptide; International Journal of Peptide & Protein Research, Oct. 1991; No. 4; pp. 340-345.
Matsuzaki, Katsumi, et al., “Interactions of an antimicrobial peptide, tachyplesin I, with lipid membranes”, Biochimica et Biophysica Acta, 1070, pp. 259-264 (1991).
Otaka, Akira, et al., “Molecular Parameters for the Anti-Human Immunodeficiency Virus Activity of T22 ([Tyr5,12, Lys7]-Polyphemusin II)1)”, Biol. Pharm. Bull. 17(12), pp. 1669-1672 (1994).
Tamamura, Hirokazu, et al., “Synthesis and Evaluation of Pseudopeptide Analogues of a Specific CXCR4 Inhibitor, T140: The Insertion of an (E)-Alkene Dipeptide Isostere into the βII′-Turn Moiety”, Bioorganic & Medicinal Chemistry Letters, vol. 12, pp. 923-928 (2002).
Demarco Steven J.
Gombert Frank
Lociuro Sergio
Moehle Kerstin
Mukherjee Reshmi
Hoffman & Baron LLP
Kosar Andrew D
Polyphor AG/Ltd.
Universität Zürich
LandOfFree
Template-fixed peptidomimetics as medicaments against HIV... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Template-fixed peptidomimetics as medicaments against HIV..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Template-fixed peptidomimetics as medicaments against HIV... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4248029