Template-directed photoligation

Details Template-directed photoligation Template-directed photoligation

1988-01-13

1993-06-15

Yarbrough, Amelia Burgess

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 243, 935 77, 935 78, C12Q 168, C07H 1512, C07H 1700, C12N 1500

Patent

active

052197344

ABSTRACT:
Methods, apparatus and compositions are presented for ligating ligands together which bind to a common target. One embodiment includes polynucleotide probes having photoreactive functional groups. The probes are capable of assuming substantially contiguous reactive positions on a target polynucleotide placing the photoreactive groups in juxtaposition. Activation of the photoreactive functional groups with radiant energy form a probe reaction product in which the probes are bound to each other.

REFERENCES:
patent: 4542102 (1985-09-01), Dattagupta et al.
Heller et al., "Homogeneous Nucleic Acid Hybridization Diagnostics by Nonradiative Energy Transfer" in Chemical Abstracts, vol. 98, 1983, Abstract 212563j.
The Condensed Chemical Dictionary, van Nostrand Reinhold Co. (1971) p. 516.

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