Temperature sensitive strain of bovine viral diarrhoea virus

Details Temperature sensitive strain of bovine viral diarrhoea virus Temperature sensitive strain of bovine viral diarrhoea virus

1986-07-31

1987-12-22

Marantz, Sidney

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

435238, 424 89, C12N 700, C12N 706, A61K 3912

Patent

active

047146788

ABSTRACT:
Disclosed is a temperature - sensitive (ts) mutant of bovine viral diarrhoea (BVD) virus which shows a considerably limited replication ability at the animal body temperature. The mutant is prepared by reacting wild-type BVD with a chemical mutagen such as nitrous acid. The mutant virous is advantageously used in vaccine compositions because it is capable of inducing immunity in bovines without causing serious side effects.

REFERENCES:
patent: 3052606 (1962-09-01), Gierer et al.
patent: 3897549 (1975-07-01), Zygraich et al.
patent: 3907986 (1975-09-01), Zygraich et al.
patent: 3962424 (1976-06-01), Zygraich et al.
patent: 4008317 (1977-02-01), Gits
Estes et al., J. Virol., 21(3):1159-1169 (1977).
Coria et al., Am. J. Vet. Res., 42(4):647-649 (1981).

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