Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1975-06-18
1976-11-16
Rosen, Sam
Drug, bio-affecting and body treating compositions
Lymphokine
195 14, A61K 3918, C12K 700
Patent
active
039925226
ABSTRACT:
A method and resulting temperature sensitive (ts) recombinants which may be produced by modifying wild-type influenza A viruses by utilization of chemically mutagenized donor viruses possessing ts lesions and shut off temperatures in the area 37.degree.-38.degree. C. Such a recombinant virus has been produced that contains the surface H3 antigen of influenza A/Hong Kong/1968 (H3N2) virus and a temperature-sensitive (ts) lesion derived from a ts mutant of influenza A/Great Lakes/1965 (H2N2) virus. Additional donor viruses include influenza A/Hong Kong/1968-ts-1[A], influenza A double recombinant 10B, and influenza A/Hong Kong/1968-ts-1[E]. When utilized as a vaccine, these temperature-sensitive recombinant viruses have the facility to develop only mild symptoms, but the infection induces complete resistant to influenzal disease produced by challenge with a virulent wild-type virus. The temperature-sensitive donor mutant is prepared chemically by growth of the virus in the presence of 5-fluorouracil (5-FU).
REFERENCES:
brdar et al., Chem. Abst., vol. 79 (1973) p. 13954v.
Chanock Robert M.
Murphy Brian R.
Ferris Thomas G.
Latker Norman J.
Roberts, Jr. John S.
Rosen Sam
The United States of America as represented by the Department of
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