Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1984-07-26
1987-07-28
Griffin, Ronald W.
Drug, bio-affecting and body treating compositions
Lymphokine
435236, 435235, 435239, A61K 2300, A61K 3912, A61K 39145, C12N 700
Patent
active
046831371
ABSTRACT:
This invention relates to a method and resulting temperature-sensitive (ts) reassortant virus produced by modifying wild-type equine influenza viruses by utilizing mutagenized human influenza viruses possessing ts lesions and shut off temperatures in the area of 37.degree.-39.degree. C., preferably 37.degree.-38.degree. C. When utilized as a vaccine for equines, these temperature-sensitive recombinant viruses have the facility to develop only mild symptoms while producing protection against infectious equine influenzal disease.
REFERENCES:
patent: 3518347 (1970-06-01), Pavilanis et al.
patent: 3869546 (1975-03-01), Lund
patent: 3920811 (1975-11-01), Lund
patent: 3992522 (1976-11-01), Chanock et al.
patent: 4009258 (1977-02-01), Kilbourne
patent: 4024235 (1977-05-01), Weetall et al.
patent: 4206287 (1980-06-01), Hannoun et al.
patent: 4318903 (1982-03-01), Lobmann et al.
patent: 4442205 (1984-04-01), Hamer et al.
patent: 4493825 (1985-01-01), Platt et al.
patent: 4500513 (1985-02-01), Brown et al.
Alexander, J. Roy. Soc. Med., vol. 75, pp. 799-811 (1982).
Masurel et al, Bull. Wid. Hith. Org., vol. 34, pp. 885-893 (1966).
Kasel et al., Bull. Wid. Hith. Org., vol. 41, pp. 447-452 (1969).
Romvory et al, Acta. Vet. Acad. Scien. Hung., vol. 24, pp. 457-461 (1974).
Rouse et al, Chemical Abstracts, vol. 72 (1970), abstract 72:98582a.
Rouse et al, Chemical Abstracts, vol. 72 (1970), abstract 72:98583b.
Pressler, Chemical Abstracts, vol. 72 (1970), abstract 72:136378y.
Frerichs et al, Chemical Abstracts, vol. 79 (1973), abstract 79:113745w.
Chemical Abstracts, CA, 77:32241K.
Chemical Abstracts, CA, 78:12247g.
Chemical Abstracts, CA, 94:116258K.
Chemical Abstracts, CA, 76:136983z.
Podchernyaeva et al, Biological Abstracts, 62:36966 (1976).
Chemical Abstracts, CA, 89:195230t.
Chemical Abstracts, CA, 79:113161c.
Chemical Abstracts, CA, 72:118773u.
Chemical Abstracts, CA, 80:92966x.
Chemical Abstracts, CA, 66:36141y.
Scholtissek et al, Virology, 118:28-34 (1982).
Brundage-Anguish et al, Am. J. Vet. Res., 43:869-894.
Kilborne, Science, 160:74-75 (1968).
Scholtissek et al, Virology, 65:325-328 (1980).
Scholtissek et al, Virology, 81:74-80 (1977).
Sherman et al, Ca-n. Vet. Jour., 18:154-158 (1977).
Sherman et al., J. Clin. Microbiol., 5:285-289 (1977).
Tolpin et al, Virology, 112:505-517 (1981).
Murphy et al, New Engl. J. Med., 286:1329-1332 (1972).
Fedson et al, J. Immunology, 107:730-737 (1971).
Van Wyke et al, J. Virol., 35:24-30 (1980).
Appleyard et al, J. Gen. Virol., 25:351-357 (1974).
Klenk, Virology, 68:426-439 (1975).
Murphy et al, Virology, 66:533-541 (1975).
Massicot et al, Virology, 101:242-249 (1980).
Tobita et al, Med. Microbiol. Immunol., 162:9-14 (1975).
Nath et al, Am. J. Vet. Res., 38:1059-1061 (1977).
Bulletin World Health Org., 58:585-591 (1980).
Spring et al, Virology, 66:533-532 (1975).
Murphy et al, Infect. and Immunity, 20:671-677 (1978).
Mills et al, J. Infect. Dis., 123:145-157 (1971).
Richman et al, J. Infect. Dis., 134:585-594 (1976).
Chanock et al, Viral Immunology and Immunopathology, 1975, Acadenuc Press, N.Y., pp. 291-316.
Murphy et al, Virology, 88:244-251 (1978).
Murphy et al, Infect. and Immunity, 20:665-670 (1978).
Jennings et al, Fed. Proc., 37:2072-2073 (1978).
Chanock et al, Rev. Infect. Dis., 2:421-431 (1980).
Murphy et al, Infect. Dis., 130:144-149 (1974).
Spring et al, Virology, 66:572-550 (1975).
Kemen, Proc. Am. Assoc. Equine Practitioners, 20:119-126 (1974).
Kemen, Hoofbeats, Jan. 1976, pp. 62-63.
Burrows, Amer. Assoc. Equine Pract., 1979, pp. 37-48.
Maassab et al, Proc. Soc. Exp. Biol. and Med., 139:768 (1972).
MacKenzie, Br. Med. J. 3:757-758 (1969).
Ingram et al, Equine Infectious Diseases IV.
Barnes et al, ed., Vet. Publ. Inc. Princeton, N.J. (1978) pp. 329-338.
Murphy et al, J. Infectious Diseases, 126:170-178 (1972).
Murphy et al, J. Infectious Diseases, 128:478-487 (1973).
Beare et al, Lancet, 2:1271-1273 (1971).
Anguish Lynne J.
Coggins Leroy
Gillespie James H.
Holmes Dorothy F.
Murphy Brian R.
Cornell Research Foundation Inc.
Griffin Ronald W.
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