Temperature sensitive gel for sustained delivery of protein drug

Details Temperature sensitive gel for sustained delivery of protein drug Temperature sensitive gel for sustained delivery of protein drug

1996-07-12

1999-01-19

Webman, Edward J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

424486, 514944, 25231501, 2523151, A61K 910, A61K 4734

Patent

active

058611746

ABSTRACT:
Pharmaceutical compositions for the delivery of pharmacologically active proteins are provided by the present invention. The compositions of the present invention comprise a polymeric matrix having thermal gelation properties in which is incorporated a discrete suspension of at least one biologically active macromolecular polypeptide which retains greater than 90 percent of its biological activity. Furthermore, the concentration of the macromolecular polypeptide is greater than 0.5 percent by weight of the composition.

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