Temperature sensitive clustered changed-to-alanine mutants of in

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant virus encoding one or more heterologous proteins...

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4242091, 435236, 536 2372, A61K 39145, C12N 704, C12N 1544

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056909373

ABSTRACT:
Recombinant PB2 variant influenza viruses, RNA, cDNA and vectors are provided. Also provided are immunogenic compositions containing the variant viruses, methods of producing such viruses and methods for the prophylactic treatment of influenza in humans.

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