Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Reexamination Certificate
2005-09-20
2005-09-20
Scheiner, Laurie (Department: 1648)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
C435S236000, C435S237000
Reexamination Certificate
active
06946136
ABSTRACT:
The present invention relates to isolated, attenuated viral strains of human parainfluenza virus 2 (HPIV-2), which are useful in live vaccine preparations. These strains exhibit a temperature sensitive and cold adapted phenotype useful for stimulating a protective immune response in an inoculated mammal without producing severe symptoms.
REFERENCES:
patent: 3927209 (1975-12-01), Straub
patent: 5869036 (1999-02-01), Belshe et al.
patent: 6165774 (2000-12-01), Cates et al.
patent: WO 96/16672 (1996-06-01), None
patent: WO 97/20468 (1997-06-01), None
patent: WO 97/38138 (1997-10-01), None
Belshe et al., Journal of Medical Virology 10:235-242, 1982.
Gross, et al. “Persistent Infection with Parainfluenza Type 3 Virus in Man.” Am. Rev. Respir. Dis, 1973, pp. 894-898, vol. 108.
Downham et al. “Diagnosis and Clinical Significance of Parainfluenza Virus Infections in Children.” Arch. Dis. Child, 1974, pp. 8-15, vol. 49.
Glezen, et al. “Effect of Passive Antibody on Parainfluenza Virus Type 3 Pneumonia in Hamsters.” Infect. Immun., 1976, pp. 212-216, vol. 14.
Parkinson, et al. “Serological Evidence for Parainfluenza Virus Infection During Isolation at South Pole Station, Antarctica.” Am. J. Epidemiol., 1980, pp. 334-340, vol. 112.
Sarkkinen, et al. “Type-Specific Detection of Parainfluenza Viruses by Enzyme-Immunoassay and Radioimmunoassay in Nasopharyngeal Specimens of Patients with Acute Respiratory Disease.” J. Gen. Virol., 1981, pp. 49-57, vol. 56.
Belshe, et al. “Cold Adaption of Parainfluenza Virus Type 3: Induction of Three Phenotypic Markers.” J. Med. Virol., 1982, pp. 235-242, vol. 10.
Welliver, et al. “Role of Parainfluenza Virus-Specific IgE in Pathogenesis of Croup and Wheezing Subsequent to infection.” J. Pediatr., 1982, pp. 889-896, vol. 101.
Storey, et al. “Structural Characterization of Virion Proteins and Genomic RNA of Human Parainfluenza Virsus 3.” J. Virol., 1984, pp. 761-766, vol. 52.
Crookshanks-Newman et al., “Protection of Weanling Hamsters from Experimental Infection with Wild-Type Parainfluenza Virus Type 3 (Para 3) by Cold-Adapted Mutants of Para3.” J. Med. Virol., 1986, pp. 131-137, vol. 18.
Ray, et al. “Immunochemistry of Paramyxoviruses.” IN “Immunochemistry of Viruses II” (M.V.H. Van Regenmortel and A.R. Neurath, eds.), 1990, pp. 215-236, Elsevier, Amsterdam.
Clements, et al. “Evaluation of Bovine, Cold-Adapted Human, and Wild-Type Human Parainfluenza Type 3 Viruses in Adult Volunteers and in Chimpanzees.” J. Clin. Microbiol., 1991, pp. 1175-1182, vol. 29.
Matsouka, et al. “The PGene of Human Parainfluenza Virus Type 1 Encodes P and C Proteins but not a Cysteine-Rich V Protein.” J. Virol., 1991, pp. 3406-3410, vol. 65.
Belshe, et al. “Evaluation of a Live Attenuated, Cold-Adapted Parainfluenza Virus Type 3 Vaccine in Children.” J. Clin. Microbiol., 1992, pp. 2064-2070, vol. 30.
Hu, et al. “Functional Interactions Between the Fusion Protein and Hemagglutinin-neuraminidase of Human Parainfluenza Viruses.” J. Virol., 1992, pp. 1528-1534, vol. 66.
Hall, et al. “A Cold-Adapted Mutant of Parainfluenza Virus Type 3 is Attenuated and Protective in Chimpanzees.” J. Infect. Dis., 1993, pp. 958-962, vol. 167.
Henrickson, et al. “Epidemiology and Cost of Infection with Human Parainfluenza Virus Types 1 and 2 in Young Children.” Clin. Infect. Dis., 1994, pp. 770-779, vol. 18.
Karron, et al. “A Live Human Parainfluenza Type 3 Virus Vaccine is Attenuated and Immunogenic in Healthy Infants and Children.” J. Infect. Dis., 1995, pp. 1445-1450, vol. 172.
Collins, et al. “Parainfluenza Viruses.” Fields Virology, Raven Press, 1996, pp. 1205-1241, vol. 1.
Belshe Robert B.
Newman Frances K.
Scheiner Laurie
Senniger Powers
St. Louis University
LandOfFree
Temperature-sensitive and cold-adapted human parainfluenza... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Temperature-sensitive and cold-adapted human parainfluenza..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Temperature-sensitive and cold-adapted human parainfluenza... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3443428