Temperature controlled content release from liposomes

Details Temperature controlled content release from liposomes Temperature controlled content release from liposomes

2005-11-15

2005-11-15

Kishore, Gollamudi S. (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

Reexamination Certificate

active

06964778

ABSTRACT:
The present invention provides a liposomal composition for targeted delivery of drugs. The composition comprises large unilamellar vesicles (LUV) encapsulating poloxamers and one or more delivery agents. The composition and concentration of the poloxamer inside the LUVs is such that upon heating to temperatures above the critical micellar temperature of the poloxamer, the LUVs becomes leaky causing release of the encapsulated drug. The present invention also provides a method for delivery of agents to targeted sites and a method for preparing the LUVs suitable for use according to the method described herein.

REFERENCES:
patent: 5364632 (1994-11-01), Benita et al.
patent: 5654000 (1997-08-01), Poli et al.
patent: 6143321 (2000-11-01), Needham et al.
patent: 6525102 (2003-02-01), Chen et al.
Bassett et al, The Journal of Urology, vol. 135, pp. 612-615, 1986.
Hayashi, et al.,Temperature-Dependent Associating Property of Liposomes Modified with a Thermosensitive Polymer,Bioconjugate Chem., 1998, vol. 9, No. 3, pp. 382-389.
Johnsson, et al.,Effect of PEO-PPO-PEO Triblock Copolymers on Structure and Stability of Phosphatidylcholine Liposomes,Langmuir, 1999, vol. 15, No. 19, pp. 6314-6325.
Kostarelos, et al.,Physical Conjugation of(Tri-)Block Copolymers to Liposomes Toward the Construction of Sterically Stabilized Vesicle Systems,Langmuir, 1999, vol. 15, No. 2, pp. 369-376.
Alexandridia et al..,Micellization of Ploy(ethylene oxide)-Poly(propylene oxide)-Poly(ethylene oxide)Triblock Copolymers in Aqueous Solutions: Thermodynamics of Copolymer Association,Macromolecules, 1994, vol. 27 No. 9, pp. 2414-2425.

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