Telomerase reverse transcriptase fragments and uses thereof

Details Telomerase reverse transcriptase fragments and uses thereof Telomerase reverse transcriptase fragments and uses thereof

2007-11-13

2007-11-13

Foley, Shanon (Department: 1642)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S325000, C435S069100

Reexamination Certificate

active

10449565

ABSTRACT:
The invention provides compositions comprising fragments of human telomerase reverse transcriptase (hTERT) which can lead to telomere dysfunction in a cell and reduction of growth and tumorigenicity in cancer cells. The invention also relates to uses of the fragments in the treatment of cancer and in drug discovery.

REFERENCES:
patent: 6166178 (2000-12-01), Cech et al.
patent: WO98/21343 (1998-05-01), None
Eck et al., (Gene-Based Therapy, In: The Pharmacological Basis ofTherapeutics, Goodman and Gilman, Ed.s, 1996, pp. 77-101.
Verma I and Somia N, Nature, 1997, vol. 389, pp. 239-242.
Orkin et al., Report and Recommendation of the Panel to Assess the NIH Investment in Research on Gene Therapy, NIH, 1995.

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