Telomerase immortalized neural progenitor cells

Details Telomerase immortalized neural progenitor cells Telomerase immortalized neural progenitor cells

2006-12-19

2006-12-19

Crouch, Deborah (Department: 1632)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

C435S368000, C435S375000, C435S455000

Reexamination Certificate

active

07150989

ABSTRACT:
The present invention relates to a method of immortalizing progenitor cells by providing a population of progenitor cells (e.g, neural progenitor cells) and immortalizing the progenitor cells either before or after they are enriched or purified. The present invention is also directed to an enriched or purified population of immortalized progenitor cells (e.g., neural progenitor cells).

REFERENCES:
patent: 4997929 (1991-03-01), Collins et al.
patent: 5082774 (1992-01-01), Heinrich
patent: 5145774 (1992-09-01), Tarnowski et al.
patent: 5169762 (1992-12-01), Gray et al.
patent: 5196315 (1993-03-01), Ronnett et al.
patent: 5217893 (1993-06-01), Ronnett et al.
patent: 5272063 (1993-12-01), Chan et al.
patent: 5308763 (1994-05-01), Ronnett et al.
patent: 5338839 (1994-08-01), McKay et al.
patent: 5491084 (1996-02-01), Chalfie et al.
patent: 5502176 (1996-03-01), Tenen et al.
patent: 5583016 (1996-12-01), Villeponteau et al.
patent: 5639618 (1997-06-01), Gay
patent: 5747317 (1998-05-01), Cao
patent: 5753505 (1998-05-01), Luskin
patent: 5753506 (1998-05-01), Johe
patent: 5830651 (1998-11-01), Cauley et al.
patent: 5874304 (1999-02-01), Zolotukhin et al.
patent: 5917025 (1999-06-01), Collins
patent: 5968829 (1999-10-01), Carpenter
patent: 5972605 (1999-10-01), Villeponteau et al.
patent: 6093809 (2000-07-01), Cech et al.
patent: 6146826 (2000-11-01), Chalfie et al.
patent: 6166178 (2000-12-01), Cech et al.
patent: 6245564 (2001-06-01), Goldman et al.
patent: 6261836 (2001-07-01), Cech et al.
patent: 6475789 (2002-11-01), Cech et al.
patent: WO 96/38541 (1996-12-01), None
patent: WO 97/07200 (1997-02-01), None
patent: WO 98/32879 (1998-07-01), None
patent: WO 99/29279 (1999-06-01), None
patent: WO 99/49014 (1999-09-01), None
patent: WO 00/23571 (2000-04-01), None
patent: WO 01/46384 (2001-06-01), None
patent: WO 01/53503 (2001-07-01), None
patent: WO 01/68815 (2001-09-01), None
Bodnar et al., “Extension of Life-Span by Introduction of Telomerase Into Normal Human Cells,”Science, 279(5349):349-352 (1998).
Klapper et al., “Differential Regulation of Telomerase Activity and TERT Expression During Brain Development in Mice,”J. Neurosci Res., 64(3):252-260 (2001).
Kruk et al., “Telomere Reduction and Telomerase Inactivation During Neuronal Cell Differentiation,”Biochem. Biophys. Res. Commun., 224(2):487-492 (1996).
Lu et al., “Telomerase Protects Developing Neurons Against DNA Damage-Induced Cell Death,”Brain Res. Dev. Brain Res., 131(1-2):167-171 (2001).
Roy et al., “Promoter-Targeted Selection and Isolation of Neural Progenitor Cells From the Adult Human Ventricular Zone,”J. Neurosci. Res., 59(3):321-331 (2000).
Wang et al., “Promoter-Based Isolation and Fluorescence-Activated Sorting of Mitotic Neuronal Progenitor Cells from the Adult Mammalian Ependymal/Subependymal Zone,”Dev. Neurosci., 22(1-2):167-176 (2000).
Zhu et al., “The Catalytic Subunit of Telomerase Neurons Against Amyloid Beta-Peptide-Induced Apoptosis,”J. Neurochem., 75(1):117-124 (2000).
Doevendans et al., “The Utility of FluorescentIn vivoReporter Genes in Molecular Cardiology,”Biochem. and Biophys. Res.222:352-358 (1996).
Prasher, “Using GFP to See the Light,”Trends in Genetics11(8):320-323 (1995).
Gloster et al., “The T alpha 1 alpha-tubulin Promoter Specifies Gene Expression as a Function of Neuronal Growth and Regeneration in Transgenic Mice,”J. Neurosci.14(12):7319-30 (1994).
Angelichio et al., “Comparison of Several Promoters and Polyadenylation Signals for Use in Heterologous Gene Expression in Cultured Drosophila Cells,”Nuc. Acids Res.19(18):5037-43 (1991).
Schatz et al., “Isolation and Characterization of Conditional-lethal Mutations in the TUB1 alpha-tubulin Gene of the YeastSaccharomyces cerevisiae,” Genetics120(3):681-95 (1988).
Schatz et al., “Insertions of up to 17 Amino Acids into a Region of alpha-tubulin Do Not Disrupt Function In Vivo,”Mol. Cell Biol.7(10):3799-805 (1987).
Schatz et al., “Genetically Essential and Nonessential alpha-tubulin Genes Specify Functionally Interchangeable Proteins,”Mol. Cell Biol.6(11):3722-33 (1986).
Schatz et al., “Two Functional alpha-tubulin Genes of the YeastSaccharomyces cerevisiaeEncode Divergent Proteins,”Mol. Cell Biol.6(11):3711-21 (1986) (abstract).
Largent et al., “Directed Expression of an Oncogene to the Olfactory Neuronal Lineage in Transgenic Mice,”J. Neuroscience13(1):300-312 (1993).
Counter et al., “Telomere Shortening Associated with Chromosome Instability is Arrested in Immortal Cells Which Express Telomerase Activity,”The EMBO Journal11:1921-1929 (1992).
Hohaus et al., “Telomerase Activity In Human Hematopoietic Progenitor Cells,”Haematologica82:262-268 (1997).
Sharma et al., “Differentiation of Immortal Cells Inhibits Telomerase Activity,”Proc. Natl. Acad. Sci. USA92:12343-12346 (1995).
Galiana et al., “Proliferation and Differentiation Properties of Biopotent Glial Progenitor Cell Lines Immortalized With the Adenovirus E1A Gene,”J. Neuro. Research36:133-146 (1993).
Raymon et al., “Immortalized Human Dorsal Root Ganglion Cells Differentiate Into Neurons With Nocieptive Properties,”J. of Neuroscience19:5420-5428 (1999).
Fu et al., “The Catalytic Subunit of Telomerase is Expressed in Developing Brain Neurons and Serves a Cell Survival-Promoting Function,”Journal of Molecular Neuroscience14:3-15 (2000).

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