Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...
Reexamination Certificate
2005-07-26
2005-07-26
Prouty, Rebecca E. (Department: 1652)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
C435S320100, C435S194000, C435S224000, C435S348000, C435S252300, C435S419000
Reexamination Certificate
active
06921664
ABSTRACT:
The present invention is directed to expression vectors comprising a polynucleotide that encodes a human telomerase reverse transcriptase (hTRT) protein, variant, or fragment. The present invention is also directed to host cells that comprise expression vectors comprising a polynucleotide that encodes a hTRT protein variant, or fragment.
REFERENCES:
patent: 3817837 (1974-06-01), Taneholtz et al.
patent: 3850752 (1974-11-01), Schuurs et al.
patent: 3939350 (1976-02-01), Kronick et al.
patent: 3996345 (1976-12-01), Ullman et al.
patent: 4275149 (1981-06-01), Litman et al.
patent: 4277437 (1981-07-01), Maggio
patent: 4366241 (1982-12-01), Tom et al.
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4683202 (1987-07-01), Mullis
patent: 4816567 (1989-03-01), Cabilly et al.
patent: 4965188 (1990-10-01), Mullis et al.
patent: 5489508 (1996-02-01), West et al.
patent: 5583016 (1996-12-01), Villeponteau et al.
patent: 5597697 (1997-01-01), Diamond
patent: 5747317 (1998-05-01), Cao
patent: 5770422 (1998-06-01), Collins
patent: 5917025 (1999-06-01), Collins
patent: 5919656 (1999-07-01), Harrington et al.
patent: 6093809 (2000-07-01), Cech et al.
patent: 6166178 (2000-12-01), Cech et al.
patent: 6258535 (2001-07-01), Villeponteau et al.
patent: 6261556 (2001-07-01), Weinrich et al.
patent: 6261836 (2001-07-01), Cech et al.
patent: 6309867 (2001-10-01), Cech et al.
patent: 6337200 (2002-01-01), Morin
patent: 6440735 (2002-08-01), Gaeta
patent: 6444650 (2002-09-01), Cech et al.
patent: 6475789 (2002-11-01), Cech et al.
patent: 6517834 (2003-02-01), Weinrich et al.
patent: 6608188 (2003-08-01), Tsuchiya et al.
patent: 6610839 (2003-08-01), Cech et al.
patent: 6617110 (2003-09-01), Cech et al.
patent: 6627619 (2003-09-01), Cech et al.
patent: 2002/0164786 (2002-11-01), Cech et al.
patent: 2002/0187471 (2002-12-01), Cech et al.
patent: 2003/0009019 (2003-01-01), Cech et al.
patent: 2003/0032075 (2003-02-01), Cech et al.
patent: 2003/0059787 (2003-03-01), Cech et al.
patent: 2003/0096344 (2003-05-01), Cech et al.
patent: 2003/0100093 (2003-05-01), Cech et al.
Adams, Mark et al. “Initial Assessment of Human Gene Diversity and Expression Patterns Based Upon 83 Million Nucleotides of cDNA Sequence”The Genome Directory: Supplement to Nature Sep. 28, 1995, pp. 3-174, vol. 377, Issue 6547S.
U.S. Appl. No. 09/432,503, Cech et al.
U.S. Appl. No. 09/721,477, Cech et al.
U.S. Appl. No. 09/721,506, Cech et al.
1994 Genome Issue ofScience(265:1981f).
Anderson and Young, “Quantitative Filter Hybridization” InNucleic Acid Hybridizationpp73-111 (1985).
Ausubal et al., Current Protocols in Molecular Biology, John Wiley & Sons, New York NY (1989).
Autexier et al., “Reconstitution of human telomerase activity and identification of a minimal functional region of the human telomerase RNA,” (1996) EMBO J, 15:5928.
Autexier, C. et al. “Telomerase and cancer: revisiting the telomere hypothesis”, Trends in Biochemical Sciences, 10 (21): 387-391 (1996).
Auxexier, and Greider “Functional reconstitution of wild-type and mutantTetrahymena telomerase,” (1994) Genes Develop., 8:563.
Avilion, A., “Characterization, and expression of human telomerase,” Dissertation Abstracts International, 56 (11) 5930-B (1996).
Barinaga, M., “The Telomerese Picture Fills In,” Science 276:528-529 (1997).
Berger and Kimmel,Guide to Molecular Cloning Techniques, Meth. Enzymol., vol. 152, Academic Press, San Diego CA (1987).
Biessmann et al., “Addition of Telomere-Associated HeT DNA Sequences “Heals” Broken Chromosome Ends in Drosophila,” Cell 61:663 [1990].
Bitter et al., “Expression and secretion vectors for yeast,” Meth Enzymol., (1987) 153:516.
Blackburn and Chiou, “Non-nucleosomal packaging of a tandemly repeated DNA sequence at termini of extrachromosomal DNA coding for rRNA in Tetrahymena,” (1981)Proc. Natl. Acad. Sci., 78:2263.
Blackburn and Gall, “A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes inTetrahymena,” (1978)J. Mol. Biol., 120:33.
Blackburn, “Telomerases,” (1992)Ann. Rev. Biochem., 61:113.
Bodnar et al., “Extension of Life-Span by Introduction of Telomerase into Normal Human Cells,” (1998) Science, 279:349.
Bradford, “A Rapid and Sensitive method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding,” (1976)Anal. Biochem., 72:248.
Braunstein et al., “Transcriptional silencing in yeast is associated with reduced nucleosome acetylation,” (1993)Genes Develop., 7:592.
Calvio et al., “Identification of hnRNP P2 as TLS/FUS using electrospray mass spectrometry,” (1995)RNA, 1:724.
Caruthers et al., “New chemical methods for synthesizing polynucleotides,” (1960)Nucleic Acids Res. Symp. Ser., 215-223.
Chan and Tye, “Organization of DNA sequences and replication origins at yeast telomeres,” (1983)Cell, 33:583.
Colbere-Garapin et al., “A new dominat hybrid selective marker for higher eukaryotic cells,” (1981)J. Mol. Biol.150:1.
Cole et al., “The EBV-hybridoma technique and its appication to human lung cancer,” Monoclonal Antibodies and Cancer Therapy, Alan R. Liss Inc., New York NY 77-96 (1985).
Collins et al., “Purification of Tetrahymena telomerase end cloning of genes encoding the two peotein components of the enzyme,” (1995)Cell, 81:677.
Collins, K., “Structure and Function of Telomerase,” Curr. Op. Cell. Biol. 8:374-380 (1998).
Conrad et al., “RAP1 protein Interacts with yeast telomers in vivo: Overproduction alters telomere structure and decreases chromosome stability,” (1990) Cell, 63:739.
Coombs,Dictionary of Biotechnology, Stockton Press, New York NY (1994).
Cote et al., “Generation at human monoclonal antibodies reactive with cellular antigens,” (1983)Proc. Natl. Acad. Sci., 80:2026.
Counter et al., “The catalytic subunit of yeast telomerase,” (1997)Proc. Natl. Acad. Sci., 94:9202.
Creighton, Proteins, Structures and Molecular Principles, WH Freeman and Co, New York NY [1983].
Dieffenbach and Dveksler,PCR Primer, a Laboratory Manual, Cold Spring Harbor Press, Plainview NY (1995).
Duplaa et al., “Quantitative analysis of polymerase chain reaction products using biotinylate dUTP incorporation,” (1993)Anal. Biochem., 212:229.
Fang et al., “Oxytricha telomere-binding protein: separable DNA-binding and dimerization domains of the α-subunit,” Genes Develop. 7:870 (1993) and Gray et al., (1991) Cell 67:807.
Gilley et al., “Altering specific telomerase RNA template residues effects active site function,” (1995)Genes Develop., 9:2214.
Gotischling and Cech, “Chromatin Structure of the Molecular Ends of Oxyricha Mononuclear DNA: Phased Nucleosomes and a Telomeric Complex,” (1984)Cell, 38:501.
Gottschling and Zakian, “Telomere proteins: specific recognition and protection of the natural termini of Oxytricha macronuclear DNA,” (1986)Cell47:195.
Grant et al., Meth Enzymol., (1987) 153:516-544.
Greenwood et al., “Phylogenetic relationships within the class oligohymenophorea, phylum ciliophora, inferred from the complete small subunit rRNA gene sequences ofColpidium campytum, Glaucoma chattoni, andOpisthonecta henneguyi,” (1991)J. Mol. Evol., 3:163.
Greider and Blackburn, “A telomeric sequence in the RNA ofTetrahymena telomeraserequired for telomere repeat synthesis,” (1989)Nature, 337:331.
Greider and Blackburn, “Identification of a specific telomere terminal transferase activity inTetrahymenaextracts,” (1985)Cell, 43:405.
Greider, “Telomerase is processive,” (1991)Mol. Cell. Biol., 11:4572.
Greider, “Telomere Length Regulation,” (1996)Ann. Rev. Biochem., 65:337.
Hampton et al.,Serological Methods a Laboratory Manual, APS Press, St Paul MN (1990).
Ha
Andrews William H.
Cech Thomas R.
Chapman Karen B.
Harley Calvin B.
Lingner Joachim
Ausenhus Scott L.
Earp David J.
Geron Corporation
Prouty Rebecca E.
Regents of the University of Colorado
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