Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1997-05-06
2000-07-25
Eyler, Yvonne
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 232, 530324, C07H 2104, A61K 3800, C07K 500, C07K 700
Patent
active
060938099
ABSTRACT:
The present invention is directed to novel telomerase nucleic acids and amino acids. In particular, the present invention is directed to nucleic acid and amino acid sequences encoding various telomerase protein subunits and motifs, including the 123 kDa and 43 kDa telomerase protein subunits of Euplotes aediculatus, and related sequences from Schizosaccharomyces, Saccharomyces sequences, and human telomerase. The present invention is also directed to polypeptides comprising these telomerase protein subunits, as well as functional polypeptides and ribonucleoproteins that contain these subunits.
REFERENCES:
patent: 3817837 (1974-06-01), Tanenholtz et al.
patent: 3850752 (1974-11-01), Schuurs et al.
patent: 3939350 (1976-02-01), Kronick et al.
patent: 3996345 (1976-12-01), Ullman et al.
patent: 4275149 (1981-06-01), Litman et al.
patent: 4277437 (1981-07-01), Maggio
patent: 4366241 (1982-12-01), Tom et al.
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4683202 (1987-07-01), Mullis
patent: 4816567 (1989-03-01), Cabilly et al.
patent: 4965188 (1990-10-01), Mullis et al.
patent: 5489508 (1996-02-01), West et al.
patent: 5583016 (1996-12-01), Villeponteau et al.
Zakian, "Telomeres: Beginning to Understand the End," Science 270:1601 [1995].
Blackburn and Gall, "A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in Tetrahymena," J. Mol. Biol., 120:33 [1978].
Oka et al., "Inverted terminal repeat sequence in the macronuclear DNA of Stylonychia pustulata," Gene 10:301 [1980].
Klobutcher et al., "All gene-sized DNA molecules in four species of hypotrichs have the same terminal sequence and an unusual 3' terminus," Proc. Natl. Acad. Sci., 78:3015 [1981].
Lingner et al., "Telomerase RNAs of different ciliates have a common secondary structure and a permuted template," Genes Develop., 8:1984 [1994].
Biessmann et al., "Addition of Telomere-Associated HeT DNA Sequences "Heals" Broken Chromosome Ends in Drosophilia," Cell 61:663 [1990].
Sheen and Levis, "Transposition of the LINE-like retrotransposon TART to Drosophilia chromosome termini," Proc. Natl. Acad. Sci., 91:12510 [1994].
Kipling and Cooke, "Hypervariable ultra-long telomeres in mice," Nature 347:400 [1990].
Starling et al., "Extensive telomere repeat arrays in mouse are hypervariable," Nucleic Acids Res., 18:6881 [1990].
Shampay and Blackburn, "Generation of telomere-length heterogeneity in Saccharomyces cerevisiae," Proc. Natl. Acad. Sci., 85:534 [1988].
Lustig and Petes, "Identification of yeast mutants with altered telomere structure," Proc. Natl. Acad. Sci., 83:1398 [1986].
Sandell et al., "Transcription of yeast telomere alleviates telomere position effect without affecting chromosome stability," Proc. Natl. Acad. Sci., 91:12061 [1994].
Chan and Tye, "Organization of DNA sequences and replication origins at yeast telomeres," Cell 33:563 [1983].
Wright et al., "Saccharomyces telomeres assume a non-nucleosomal chromatin structure," Genes Develop., 6:197 [1992].
Gottschling and Cech, "Chromatin Structure of the Molecular Ends of Oxytricha Macronuclear DNA: Phased Nucleosomes and a Telomeric Complex," Cell 38:501 [1984].
Blackburn and Chiou, "Non-nucleosomal packaging of a tandemly repeated DNA sequence at termini of extrachromosomal DNA coding for rRNA in Tetrahymena," Proc. Natl. Acad. Sci., 78:2263 [1981].
Braunstein et al., "Transcriptional silencing in yeast is associated with reduced nucleosome acetylation," Genes Develop., 7:592 [1993].
Makarov et al., "Nucleosomal Organization of Telomere-Specific Chromatin in Rat," Cell 73:775 [1993].
Tommerup et al., "Unusual chromatin in human telomeres," Mol. Cell. Biol., 14:5777 [1994].
Watson, "Origin of concatemeric T7 DNA," Nature New Biol., 239:197 [1972].
J. Olovnikov, "A theory of marginotomy: The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon," J. Theor. Biol., 41:181 [1973].
Henderson and Blackburn, "An overhanging 3' terminus is a conserved feature of telomeres," Mol. Cell. Biol., 9:345 [1989].
Wellinger et al., "Saccharomyces Telomeres Acquire Single-Strand TG.sub.1-3 Tails Late in S Phase," Cell 72:51 [1993].
Zahler and Prescott, "Telomere terminal transferase activity in the hypotrichous ciliate Oxytricha nova and a model for replication of the ends of linear DNA molecules," Nucleic Acids Res., 16:6953 [1988].
Lingner et al., "Telomerase and DNA End Replication: No Longer a Lagging Strand Problem?," Science 269:1533 [1995].
Yu et al., "In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs," Nature 344:126 [1990].
Singer and Gottschling, "TLC1: Template RNA Component of Saccharomyces cerevisiae Telomerase," Science 266:404 [1994].
Autexier and Greider, "Functional reconstitution of wild-type and mutant Tetrahymena telomerase," Genes Develop., 8:563 [1994].
Gilley et al., "Altering specific telomerase RNA template residues affects active site function," Genes Develop., 9:2214 [1995].
McEachern and Blackburn, "Runaway telomere elongation caused by telomerase RNA gene mutation," Nature 376:403 [1995].
Blackburn, "Telomerases," Ann. Rev. Biochem., 61:113 [1992].
Greider, "Telomere Length Regulation," Ann. Rev. Biochem., 65:337 [1996].
Greider, "Telomerase is processive," Mol. Cell. Biol., 11:4572 [1991].
Wellinger et al., "Origin activation and formation of single-strand TG.sub.1-3 tails occur sequentially in late S phase on a Yeast linear plasmid," Mol. Cell. Biol., 13:4057 [1993].
Prescott, "The DNA of ciliated protozoa," Microbiol. Rev., 58:233 [1994].
Greenwood et al., "Phylogenetic relationships within the class oligohymenophorea, phylum cilophora, inferred from the complete small subunit rRNA gene sequences of Colpidium campylum, Glaucoma chattoni, and Opisthonecta henneguyi," J. Mol. Evol., 3:163 [1991].
Berger and Kimmel, Guide to Molecular Cloning Techniques, Meth. Enzymol. vol. 152, Academic Press, San Diego CA [1987].
CCaruthers et al., "New chemical methods for synthesizing polynucleotides," Nucleic Acids Res. Symp. Ser., 215-223 [1980].
Horn et al., "Synthesis of oligonucleotides on cellulose. Part II: design and synthetic strategy to the synthesis of 22 oligodeoxynucleotides coding for gastric inhibitory polypeptide (GIP)," Nucleic Acids Res. Symp. Ser., 225-232 [1980].
Roberge, et al., "A strategy for a convergent synthesis of N-linked glycopeptides on a solid support," Science 269:202 [1995].
Creighton, Proteins, Structures and Molecular Principles, WH Freeman and Co, New York NY [1983].
Sambrook et al. (1989) Molecular Cloning, A Laboratory Manual, Cold Spring Harbor Press, Plainview NY.
Ausubel et al. (1989) Current Protocols in Molecular Biology, John Wiley & Sons, New York NY.
Grant et al., Meth. Enzymol., 153:516-544 (1987).
Scharf D et al., "Heat stress promoters and transcription factors," Results Probl. Cell Differ. 20:125 [1994].
Bitter et al., "Expression and secretion vectors for yeast," Meth. Enzymol., 153:516 [1987].
Wigler et al., "Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells," Cell 11:223-32 [1977].
Lowy et al., "Isolation of transforming DNA: Cloning the hampster aprt gene," Cell 22:817 [1980].
Wigler et al., "Transformation of mammalian cells with an amplifiable dominant-acting gene," Proc. Natl. Acad. Sci., 77:3567 [1980].
Colbere-Garapin et al., "A new dominant hybrid selective marker for higher eukaryotic cells," J. Mol. Biol., 150:1 [1981].
Murry, In McGraw Hill Yearbook of Science and Technology, McGraw Hill, New York NY, pp. 191-196 [1992].
Hartman and Mulligan, "Two dominant-acting selectable markers for gene transfer studies in mammalian cells," Proc. Natl. Acad. Sci., 85:8047 [1988].
Rhodes et al., "Transformation of maize by electroporation of embryos," Meth. Mol. Biol., 55:121 [1995].
Hampton et al., Serological Methods a Laboratory Manual, APS Press, St Paul MN [1990].
Maddox et al., "Elevated serum levels in human pregnancy of a molecule immunochemically similar to eosinophil granule major basic protein," J. Exp. Med., 158:1211 [1983].
Cech Thomas R.
Lingner Joachim
Eyler Yvonne
Geron Corporation
University Technology Corporation
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