Surgery – Means for introducing or removing material from body for... – Material introduced into and removed from body through...
Patent
1997-07-29
1998-09-29
Buiz, Michael Powell
Surgery
Means for introducing or removing material from body for...
Material introduced into and removed from body through...
604 93, A61M 300
Patent
active
058140140
ABSTRACT:
Techniques for infusing drugs into the brain to treat neurodegenerative disorders by system of an implantable pump and catheter. The drugs are capable of altering the level of excitation of neruons in the brain. A sensor is used to detect an attribute of the nervous system which reflects the hyperexcitation of the nerve cells projecting onto the degenerating nerve cells. A microprocessor algorithm analyzes the output from the sensor in order to regulate the amount of drug delivered to the brain.
REFERENCES:
patent: 3957036 (1976-05-01), Normann
patent: 4146029 (1979-03-01), Ellinwood, Jr.
patent: 4256437 (1981-03-01), Brown
patent: 4576556 (1986-03-01), Thompson
patent: 4692147 (1987-09-01), Duggan
patent: 5011472 (1991-04-01), Aebischer et al.
patent: 5293879 (1994-03-01), Vonk et al.
patent: 5474547 (1995-12-01), Aebischer
patent: 5713858 (1998-02-01), Heruth et al.
patent: 5713888 (1998-02-01), Neuenfeldt et al.
patent: 5735814 (1998-04-01), Elsberry et al.
Duncan et al., "Thalamic VPM Nucleus In The Behaving Monkey, III. Effects of Reversible Inactivation by Lidocaine on Thermal and Mechanical Discrimination," J. Neurophysiology, vol. 70, No. 5, pp. 2086-2096 (1994).
Bobo et al., "Convection-enhanced delicery of macromolecules in the brain," Proc. Natl. Acad. Sci. USA, 91, pp. 2076-2080 (1994).
Crossman et al., "Experimental Herniballismus In The Babbon Produced By Injection Of A Gamma-Aminobutyric Acid Antagonis Into The Basal Ganglia," Neuroscience Letters, 20 pp. 369-372 (1980).
Graham et al., "Injection of Excitatory Amino Acid Antagonists Into The Medial Pallidal Segment of a 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Treated Primate Reverses Motor Symptoms of Parkinsonism", Life Sciences, 47, pp. 91-97 (1990).
van Horne et al., "Multichannel Semiconductor-based electrodes for in vivo electrochemical and electrophysical studies in rat CNS", Neuroscience Letters, 120, pp. 249-252 (1990).
Couratier et al., "Cell culture evidence for neuronal degeneration in amyotrophic lateral sclerosis being linked to glutamate AMPA/kainate receptors", The Lancet, vol. 341, pp. 265-268 (Jan. 30, 1993).
Shaw et al., "Studies on Cellular Free Radical Protection Mechanism in the Anterior Horn from Patients with Amyotrophic Lateral Sclerosis", Neurodegeneration, vol. 4, pp. 391-396 (1995).
Yamauchi et al., "Corpus Callosum atrophy in amyotrophic lateral sclerosis", J. Neurological Sciences, 134, pp. 189-196 (1995).
Hollander et al., "High-dose Dextromethorphan in Amyotrophic Lateral Sclerosis: Phase I Safety and Pharmacokinetic Studies", Ann. Neurol. 36, pp. 920-924 (1994).
Nihei et al., "NPY Immunoreactive Neurons Are Involved In the Degeneration Of Amyotrophic Lateral Sclerosis", Biomedical Research 15, Suppl. 2, pp. 209-212 (1994).
Lanius et al., "A Role for Amplified Protein Kinase C Activity in the Pathogenesis of Amyotrophic Lateral Sclerosis", J. Neurochemistry, pp. 927-930 (1995).
Appel, "Excitotoxic neuronal cell death in amyotrophic lateral sclerosis", TINS vol. 16, No. 1, pp. 3-5 (1993).
Rothman et al., "Excitotoxicity and the NMDA receptor", TINS vol. 10, No. 7, pp. 299-302 (1987).
Benabid et al., "Long-term suppression of tremor by chronic stimulation of the ventral intermediate thalamic nucleus", The Lancet, vol. 337, pp. 403-406 (1991).
Benabid et al., "Vim and STN Stimulation in Parkinson's Disease", Movement Disorders, vol. 9, Suppl. 1, Abstract M39 (1994).
Limousin et al., "Effect on Parkinsonian signs and symptoms of bilateral subthalamic nucleus stimulation", The Lancet, vol. 345, pp. 91-95 (1995).
Bensimon et al., "A Controlled Trial of Riluzole in Amyotrophic Lateral Sclerosis", The New England Journal of Medicine, vol. 330, No. 9, pp. 585-591 (1994).
A. Depaulis et al., "Suppressive effects of intranigral injection of muscimol in three models of generalized non-convulsive epilepsy induced by chemical agents", Brain Research, 498 (1989) 64-72.
Dill et al., "Dyskinesias in Rats following Chemical Stimulation of the Neostriatum", Texas Reports on Biology and Medicine, vol. 26, No. 1, Spring (1968).
Godsey et al., "Omnitrode: A Simple Cannula for Chemical and Bipolar Electrical Stimulation", Physiology and Behavior, vol. 8, pp. 773-775, Brain Research Publications Inc. 1972 (Great Britain).
Kroll et al., "Increasing volume of Distribution to the Brain with Interstitial Infusion: Dose, Rather Than convection, Might be the Most Important Factor", Neurosurgery, vol. 38, pp. 746-754 (1996).
May et al., "Intrastriatal Infusion of Lisuride-a Potential Treatment for Parkinson's disease? Behavioral and Autoradiographic Studies in 6-OHDA Lesioned Rats", Neurodegeneration, vol. 3, pp. 305-313 (1994).
Elsberry Dennis D.
Rise Mark T.
Buiz Michael Powell
Medtronic Incorporated
Truong Kevin
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