Surgery – Means for introducing or removing material from body for... – Material introduced into and removed from body through...
Patent
1996-04-30
1998-04-07
Buiz, Michael
Surgery
Means for introducing or removing material from body for...
Material introduced into and removed from body through...
604 49, A61K 922
Patent
active
057358141
ABSTRACT:
Techniques for infusing drugs into the brain to treat neurodegenerative disorders by an implantable pump and catheter. The drugs are capable of altering the level of excitation of neruons in the brain. A sensor is used to detect an attribute of the nervous system which reflects the hyperexcitation of the nerve cells projecting onto the degenerating nerve cells. A microprocessor algorithm analyzes the output from the sensor in order to regulate the amount of drug delivered to the brain.
REFERENCES:
patent: 4692147 (1987-09-01), Duggan
patent: 5293879 (1994-03-01), Vonk et al.
patent: 5403278 (1995-04-01), Ernst et al.
patent: 5487739 (1996-01-01), Aebischer et al.
Duncan et al., "Thalamic VPM Nucleus In The Behaving Monkey, III. Effects of Reversible Inactivation by Lidocaine on Thermal and Mechanical Discrimination," J. Neurophysiology, vol. 70, No. 5, pp. 2086-2096 (1993).
Bobo et al., "Convection-enhanced delivery of macromolecules in the brain," Proc. Natl. Acad. Sci. USA, 91, pp. 2076-2080 (1994).
Crossman et al., "Experimental Hemiballismus In The Baboon Produced By Injection Of A Gamma-Aminobutyric Acid Antagonist Into The Basal Ganglia," Neuroscience Letters, 20 pp. 369-372 (1980).
Graham et al., "Injection of Excitatory Amino Acid Antagonists Into The Medial Pallidal Segment of a 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Treated Primate Reverses Motor Symptoms Of Parkinsonism", Life Sciences, 47, pp. 91-97 (1990).
van Horne et al., "Multichannel Semiconductor-based electrodes for in vivo electrochemical and electrophysical studies in rat CNS", Neuroscience Letters. 120, pp. 249-252 (1990).
Couratier et al., "Cell culture evidence for neuronal degeneration in amyotrophic lateral sclerosis being linked to glutamate AMPA/kainate receptors", The Lancet, vol. 341 (Jan. 30, 1993).
Shaw et al., "Studies on Cellular Free Radical Protection Mechanisms in the Anterior Horn from Patients with Amyotrophic Lateral Sclerosis", Neurodegeneration, vol. 4, pp. 391-396 (1995).
Yamauchi et al., "Corpus Callosum atrophy in amyotrophic lateral sclerosis", J. Neurological Sciences, 134, pp. 189-196 (1995).
Hollander et al., "High-dose Dextromethorphan in Amyotrophic Lateral Sclerosis: Phase I Safety and Pharmacokinetic Studies", Ann. Neurol. 36, pp. 920-924 (1994).
Nihei et al., "NPY Immunoreactive Neurons Are Involved In the Degeneration Of Amyotrophic Lateral Sclerosis", Biomedical Research 15, Suppl. 2, pp. 209-212 (1994).
Lanius et al., "A Role for Amplified Protein Kinase C Activity in the Pathogenesis of Amyotrophic Lateral Sclerosis", J. Neurochemistry, p. 927 (1995).
Appel, "Excitotoxic neuronal cell death in amyotrophic lateral sclerosis", TINS , vol. 16, No. 1, pp. 3-5 (1993).
Rothman et al., "Excitotoxicity and the NMDA receptor", TINS vol. 10, No. 7, pp. 299-302 (1987).
Benabid et al., "Long-term suppression of tremor by chronic stimulation of the ventral intermediate thalamic nucleus", The Lancet, vol. 337, pp. 403-406 (1991).
Benabid et al., "Vim and STN Stimulation in Parkinson's Disease", Movement Disorders, vol. 9, Suppl. 1, Abstract M39 (1994).
Limousin et al., "Effect on Parkinsonian signs and symptoms of bilateral subthalamic nucleus stimulation", The Lancet, vol. 345, pp. 91-95 (1995).
Bensimon et al., "A Controlled Trial of Riluzole in Amyotrophic Lateral Sclerosis", The New England Journal of Medicine, vol. 330, No. 9, pp. 585-591 (1994).
Elsberry Dennis D.
Rise Mark T.
Buiz Michael
Medtronic Inc.
Truong Kevin
LandOfFree
Techniques of treating neurodegenerative disorders by brain infu does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Techniques of treating neurodegenerative disorders by brain infu, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Techniques of treating neurodegenerative disorders by brain infu will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-8317