Surgery: light – thermal – and electrical application – Light – thermal – and electrical application – Electrical therapeutic systems
Patent
1997-10-24
1999-11-02
Kamm, William E.
Surgery: light, thermal, and electrical application
Light, thermal, and electrical application
Electrical therapeutic systems
604 50, 604 67, 6048911, A61N 100
Patent
active
059787023
ABSTRACT:
Techniques using one or more drugs and electrical stimulation for treating a neurological disorder, including epilepsy, by means of an implantable signal generator and electrode and an implantable pump and catheter. A sensor is used to detect a seizure or symptoms resulting from the onset of a seizure. A microprocessor algorithm analyzes the output from the sensor in order to regulate the stimulation and drug dosage delivered to the neural tissue.
REFERENCES:
patent: 3993046 (1976-11-01), Fernandez et al.
patent: 4692147 (1987-09-01), Duggan
patent: 4702254 (1987-10-01), Zabara
patent: 4867164 (1989-09-01), Zabara
patent: 5025807 (1991-06-01), Zabara
patent: 5031618 (1991-07-01), Mullett
patent: 5154172 (1992-10-01), Terry, Jr. et al.
patent: 5269303 (1993-12-01), Wernicke et al.
patent: 5293879 (1994-03-01), Vonk et al.
patent: 5299569 (1994-04-01), Wernicke et al.
patent: 5474547 (1995-12-01), Aebischer et al.
patent: 5522863 (1996-06-01), Spano et al.
patent: 5540734 (1996-07-01), Zabara
patent: 5676655 (1997-10-01), Howard et al.
patent: 5683422 (1997-11-01), Rise
patent: 5707396 (1998-01-01), Benabid
patent: 5711316 (1998-01-01), Elsberry et al.
patent: 5713923 (1998-02-01), Ward et al.
patent: 5716377 (1998-02-01), Rise et al.
patent: 5735814 (1998-04-01), Elsberry et al.
patent: 5752979 (1998-05-01), Benabid
patent: 5792186 (1998-08-01), Rise
patent: 5800474 (1998-09-01), Benabid et al.
patent: 5832932 (1998-11-01), Elsberry et al.
patent: 5833709 (1998-11-01), Rise et al.
van Horne et al., "Multichannel Semiconductor-based electrodes for in vivo electrochemical and electrophysical studies in rat CNS", Neuroscience Letters, 120, pp. 249-252 (1990).
Benabid et al., "Long-term suppression of tremor by chronic stimulation of the ventral intermediate thalamic nucleus", The Lancet, vol. 337, pp. 403-406 (1991).
Benabid et al., "Vim and STN Stimulation in Parkinson's Disease", Movement Disorders, vol. 9, Suppl. 1, Abstract M39 (1994).
Limousin et al., "Effect on Parkinsonian signs and symptoms of bilateral subthalamic nucleus stimulation", The Lancet, vol. 345, pp. 91-95 (1995).
Bergman et al., "Reversal of Experimental Parkinsonism by Lesions of the Subthalamic Nucleus", Science, 249:1436-1438 (1990).
Depaulis et al., "Endogenous Control of Epilepsy: The Nigral Inhibitory System", Progress in Neurobiology, 42:33-52 (1994).
Gale, "Mechanisms of Seizure Control Mediated by Gamma-Aminbutyric Acid: Role of the Substantia Nigra", Federal Proceedings vol. 44(8):2414-2424 (1985).
Cooper et al., "The Effect of Chronic Stimulation of Cerebellar Cortex on Epilepsy in Man", The Cerebellum, Epilepsy Behavior, Cooper Riklan and Snider ed. Plenum Press, NY. pp. 119-171 (1974).
Velasco et al., "Electrical Stimulation of the Centromedian Thalamic Nucleus in Control of Seizures: Long-Term Studies" Epilepsia, 36(1):63-71 (1995).
Sussman et al., "Anterior Thalamic Stimulation in Medically Intractable Epilepsy Part II: Preliminary Clinical Results", Epilepsia, 29, No. 5 (1988).
Durand, "Electrical Stimulation Can Inhibit Synchronized Neuronal Activity", Brain Research: 382, 139-144 (1986).
Durand et al., "Desynchronization of Epiletiform Activity by Extracellular Current Pulses in Rat Hippocampal Slices", Journal of Physiology, 480.3, pp. 527-537 (1994).
Schiff et al., "Controlling Chaos in the Brain", Nature, vol. 340, pp. 615-620 (Aug. 25, 1994).
Smith et al., "Rabid Cessation of Focally Induced Generalized Seizures in Rats Through Microfusion of Lidocaine Hydrochloride into the Focus", Epilepsia, 34(1):43-53 (1993).
Depaulis et al., "Suprressive Effects of Intranigral Injection of Muscimol in Three Models of Generalized Non-Convulsive Epilepsy Induced by Chemical Agents", Brain Research, 498:64-72 (1989).
Mirski et al., "Anterior Thalamus and Substantia Nigra: Two Distinct Structures Mediating Experimental Generalized Seizures", Brain Research, 397:377-380 (1986).
Qu et al., "A Seizure Warning System for Long-Term Epilepsy Monitoring", Neurology 45:2250-2254 (1995).
Osorio et al., "A Method for Accurate Automated Real-Time Seizure Detection", Epilepsia, vol. 36, Supplement 4 (1995).
Crichton, "The Terminal Man", First Ballatine Books Edition (Jan. 1988), pp. 16-27 (Copyright 1972).
Moss, "Chaos Under Control", Nature, vol. 370, pp. 596-620, (1994).
Martinez et al., "Toxicology and Kinetics of Long-Term Intraventricular Infusion of Phenytoin and Valproic Acid in Pigs: Experimental Study", Acta Neurochirurgica, Suppl. 52, pp. 3-4 (1991).
Durand et al., "Control of Abnormal Electrical Activity with Applied Electrical Fields", IEEE Engineering in Medicine & Biology Society 10th Annual International Conference, (1988).
Glanz, "Do Chaos-Control Techniques Offer Hope for Epilepsy," Science, vol. 265, p. 1174 (Aug. 26, 1994).
Alexander et al., "Basal Ganglia-thalamocortical Circuits: Parallel Substrates for Motor, Oculomotor, `Prefrontal` and `Limbic` Functions", Progress in Brain Res. 85:119-146 (1990).
Darder, Gomez, Guerro, Pastor, Gil-Salu, "Intrathecal Antiepiletic Drugs in Experimental Epilepsy" Sterotact Funct Neurosurg, (1991) :57:147-155.
Rise Mark T.
Ward Scott R.
Evanisko George R.
Kamm William E.
Medtronic Inc.
LandOfFree
Techniques of treating epilepsy by brain stimulation and drug in does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Techniques of treating epilepsy by brain stimulation and drug in, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Techniques of treating epilepsy by brain stimulation and drug in will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2149069