Techniques for synthesis integrity evaluation utilizing cycle fi

Details Techniques for synthesis integrity evaluation utilizing cycle fi Techniques for synthesis integrity evaluation utilizing cycle fi

1998-08-31

2000-10-10

Fredman, Jeffrey

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 911, 435 94, 530350, 702 19, 702 20, 536 253, C12Q 160, G01N 3348, C12P 1934, C07H 2100

Patent

active

061300462

ABSTRACT:
Techniques for designing polymer probes to verify the integrity of the probe synthesis are provided. Multiple probes with identical sequences are designed so that the probes will be formed utilizing at least one different monomer addition cycle. Based on the probes affinity to a control target, variations (e.g., errors) in probe synthesis may be identified.

REFERENCES:
patent: 5143854 (1992-09-01), Pirrung et al.
McGall et al, "Light-directed synthesis of high-density oligonucleotide arrays using semiconductor photoresists", Proc. Natl. Acad. Sci. 93:13555-13560, Nov. 1996.
Pirrung et al, "Comparison of methods for photochemical phosphoramidite based DNA synthesis"J. Org. Chem. 60:6270-6276, 1995.

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