Coating processes – Measuring – testing – or indicating
Patent
1997-09-22
1999-05-04
Dudash, Diana
Coating processes
Measuring, testing, or indicating
427 23, 427 231, 427230, 427384, 324 711, 324 93, 324439, B05D 310, B05D 500, B05D 722, G01N 2700
Patent
active
059002700
ABSTRACT:
The integrity of a microporous membrane within a mass transfer device such as an oxygenator is tested simultaneously with applying a biocompatible surfactant to at least the blood-contact surface of the membrane. The membrane integrity test contacts both sides of the microporous membrane with a conductive fluid to establish an electrical circuit. An electrical signal is then applied to the circuit and a measurement is taken of the test voltage across an impedance in the circuit. The value of the test voltage is used to determine the conductivity and thus the integrity of the membrane. The biocompatible surfactant is mixed with the conductive fluid used in the electrical integrity test and has an affinity for the microporous membrane material so that a durable biocompatible coating is applied to at least a portion of the microporous membrane. The biocompatible surfactant additionally reduces the drying time of the microporous membrane following the integrity test, and the surfactant may be applied to both sides of the membrane to further reduce the drying time.
REFERENCES:
patent: 2012762 (1935-08-01), Kern
patent: 2297837 (1942-10-01), Loughnane
patent: 2622129 (1952-12-01), Killian
patent: 2981886 (1961-04-01), Beck
patent: 3252155 (1966-05-01), Surtees et al.
patent: 3254526 (1966-06-01), Yarbrough
patent: 3383863 (1968-05-01), Berry
patent: 3414808 (1968-12-01), Thomas
patent: 3811317 (1974-05-01), Leonard et al.
patent: 3855531 (1974-12-01), Fielibert et al.
patent: 3937064 (1976-02-01), Wolf, Jr. et al.
patent: 4239729 (1980-12-01), Hasegawa et al.
patent: 4267295 (1981-05-01), Gallop et al.
patent: 4355109 (1982-10-01), Zajic et al.
patent: 4540407 (1985-09-01), Dunn
patent: 4583039 (1986-04-01), Kolcio et al.
patent: 4704203 (1987-11-01), Reed
patent: 4705709 (1987-11-01), Vailancourt
patent: 4749585 (1988-06-01), Greco et al.
patent: 4810971 (1989-03-01), Marable
patent: 4909069 (1990-03-01), Albin et al.
patent: 4956635 (1990-09-01), Langdon
patent: 5036309 (1991-07-01), Dennison, Jr.
patent: 5049275 (1991-09-01), Gillberg-LaForce et al.
patent: 5059913 (1991-10-01), Nigro et al.
patent: 5061738 (1991-10-01), Solomon et al.
patent: 5091205 (1992-02-01), Fan
patent: 5109215 (1992-04-01), Dennison
patent: 5114425 (1992-05-01), Williams et al.
patent: 5135516 (1992-08-01), Sahatjian et al.
patent: 5162102 (1992-11-01), Nogawa et al.
patent: 5165952 (1992-11-01), Solomon et al.
patent: 5196799 (1993-03-01), Beard et al.
patent: 5204632 (1993-04-01), Leach
patent: 5214387 (1993-05-01), Fenner
patent: 5290918 (1994-03-01), Bui-Khac
patent: 5295978 (1994-03-01), Fan et al.
patent: 5351008 (1994-09-01), Leach et al.
patent: 5395923 (1995-03-01), Bui-Khac et al.
patent: 5429802 (1995-07-01), Hagiwara et al.
patent: 5447724 (1995-09-01), Helmus et al.
patent: 5451424 (1995-09-01), Solomon et al.
patent: 5455108 (1995-10-01), Quincy et al.
patent: 5477155 (1995-12-01), Proulx et al.
patent: 5496637 (1996-03-01), Parham et al.
patent: 5525415 (1996-06-01), Quincy, III et al.
patent: 5540984 (1996-07-01), Quincy, III et al.
patent: 5569463 (1996-10-01), Helmus et al.
patent: 5584875 (1996-12-01), Duhamel et al.
patent: 5643681 (1997-07-01), Voorhees et al.
ICI Speciality Chemicals, "Types of Surfactants From ICI Speciality Chemicals"; no date.
ICI Surfactants; "Guide to ICI Surfactants"; ICI Americas, Inc.; Feb. 1994; pp. 1-8, 21, and 24.
"Prevention of protein adsorption and platelet adhesion on surfaces by PEO/PPO/PEO triblock copolymers"; M. Amiji and K. Park; Biomaterials, 1992, vol. 13, No. 10; pp. 682-692. (no month).
"Protein resistant surfaces prepared by PEO-containing block copolymer surfactants"; Jourmal of Biomedical Research; vol. 23, pp. 351-368; 1989. (no month).
"Pluronic & Tetronic Block Copolymer Surfactants"; BASF Corporation, 1989, (no month).
"BASF Performance Chemicals"; BASF Corporation, 1991. (no month).
Technical Bulletin, "Plurafac RA-20 Linear Alcohol Alkoxylate"; Industrial and Performance Chemicals; BASF Corporation; 1987. (no month.
Article, "Microemboli Observed in Deaths Following Cardiopulmonary Surgery: Silicone Antifoam Agents and Polyvinyl Chloride Tubing as Sources of Emboli"; Orensetine et al.; Human Pathology; vol. 13, No. 12, Dec. 1982, pp. 1082-1090.
Article, "A comparison of Pluronic F-68, low molecular weight dextran, mannitol, and saline as priming agents in the heart-lung apparatus, Part I Pluronic F-68; First use as a plasma substitute"; Hymes et al. ; Journal of Thoracic and Cardiovascular Surgery; vol. 56, No. 1; Jul. 1968; pp. 16-22.
Chapter 10, "Polyalkylene Oxide Block Copolymers"; Nonionic Surfactants; pp. 300-371; 1967. (no month).
Article, "Adjunctive Use of a Surface-Active Agent in Extracorporeal Circulation"; Yoshimasa et al.; Supplement to Circulation, vol. XXXIII and XXXIV, Apr. 1966, pp. I-71 to I-77.
Article, "Fat globulemia in extracorporeal circulation", Wright et al.; Surgery, Apr. 1963, pp. 500-504.
Clark Tom L.
McBurney Laura L.
Smith, III Hubert S.
Cobe Laboratories, Inc.
Dudash Diana
Ley John R.
Phillips John B.
LandOfFree
Technique for testing and coating a microporous membrane does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Technique for testing and coating a microporous membrane, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Technique for testing and coating a microporous membrane will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1868825