Technique for extracting arrayed data

Details Technique for extracting arrayed data Technique for extracting arrayed data

2004-12-20

2008-12-16

Werner, Brian P (Department: 2624)

Image analysis

Applications

Biomedical applications

C382S190000

Reexamination Certificate

active

07466851

ABSTRACT:
The current invention discloses a novel spectral transformation technique for characterizing digitized intensity output patterns from microarrays. This method yields improved sensitivity with reduced false positives and false negatives. Current microarray methods are overly sensitive to the detection of a visible distinction between pixels associated with probes and pixels associated with background. In one embodiment, a technique is disclosed that comprises the steps of: extracting pixels associated with an object of interest and transforming such pixels from an intensity representation to a spectral representation. In some embodiments, the extraction is based on a tessellated logarithmic spiral extraction that may yield a pixel core with a sampling of both foreground and background pixels. This core may then be computationally rescaled by 10×-10,000× to enhance spatial resolution. Once the extracted pixels are represented in the spectral regime, convolution with resolution-enhancement kernels may be used to accentuate morphological features capturing platform specific phenomenology.

REFERENCES:
patent: 5371669 (1994-12-01), Venkataraman et al.
patent: 5371834 (1994-12-01), Tawel
patent: 5631734 (1997-05-01), Stern
patent: 5733729 (1998-03-01), Lipshutz
patent: 5784162 (1998-07-01), Cabib et al.
patent: 5812272 (1998-09-01), King et al.
patent: 5822466 (1998-10-01), Morfill
patent: 5858659 (1999-01-01), Sapolsky
patent: 5925525 (1999-07-01), Fodor
patent: 5968740 (1999-10-01), Fodor
patent: 5974164 (1999-10-01), Chee
patent: 6025601 (2000-02-01), Trulson
patent: 6066454 (2000-05-01), Lipshutz
patent: 6090555 (2000-07-01), Fiekowsky
patent: 6136541 (2000-10-01), Gulati
patent: 6142681 (2000-11-01), Gulati
patent: 6165734 (2000-12-01), Garini et al.
patent: 6171793 (2001-01-01), Phillips
patent: 6185561 (2001-02-01), Balaban
patent: 6218122 (2001-04-01), Friend
patent: 6223127 (2001-04-01), Berno
patent: 6225625 (2001-05-01), Pirrung
patent: 6228593 (2001-05-01), Lipshutz
patent: 6229911 (2001-05-01), Balaban
patent: 6242180 (2001-06-01), Chee
patent: 6245511 (2001-06-01), Gulati
patent: 6294327 (2001-09-01), Walton
patent: 6308170 (2001-10-01), Balaban
patent: 6342355 (2002-01-01), Hacia
patent: 6344316 (2002-02-01), Lockhart
patent: 6349144 (2002-02-01), Shams
patent: 6361937 (2002-03-01), Stryker
patent: 6368799 (2002-04-01), Chee
patent: 6370478 (2002-04-01), Stoughton
patent: 6391550 (2002-05-01), Lockhart et al.
patent: 6420108 (2002-07-01), Mack
patent: 6453241 (2002-09-01), Bassett
patent: 6468744 (2002-10-01), Cronin
patent: 6485913 (2002-11-01), Becker et al.
patent: 6490533 (2002-12-01), Weiner
patent: 6495363 (2002-12-01), Bogdanov
patent: 6498863 (2002-12-01), Gaidoukevitch et al.
patent: 6542638 (2003-04-01), Campbell
patent: 6567750 (2003-05-01), Nadon
patent: 6571005 (2003-05-01), Li
patent: 6671625 (2003-12-01), Gulati
patent: 6704662 (2004-03-01), Gulati
patent: 6716629 (2004-04-01), Hess et al.
patent: 2001/0033364 (2001-10-01), Cabib et al.
patent: 2002/0052882 (2002-05-01), Taylor
patent: 2003/0044775 (2003-03-01), Gulati
patent: 2003/0071843 (2003-04-01), Hoff
patent: 2003/0112446 (2003-06-01), Miller et al.
patent: 2003/0219150 (2003-11-01), Niles et al.
patent: 2003/0235840 (2003-12-01), Ward et al.
patent: 1 089 067 (2001-04-01), None
patent: 1162572 (2001-12-01), None
Kuklin, et al., High throughput screening of gene expression signature, 2000, pp. 41-46.
Cheung et al., Analysis of gene microarray images, 1999, pp. 627-632.
PCT/US03/14182 to Viology Corp.

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