Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1986-08-05
1989-01-31
Lovering, Richard D.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
128804, 264 43, 4284022, 436829, 424 11, A61K 966, A61K 3722, B01J 1302
Patent
active
048014591
ABSTRACT:
A technique for rapidly delivering drugs and/or chemicals to a specific area of the body by subjecting a liposome encapsulated drug and/or chemical to nonionizing electromagnetic fields. By subjecting the liposome to such fields in the range of 26-2,450 MHz drug/chemical release occurs in a rapid fashion and at temperatures that the liposomes are normally not leaky. This is a non-thermal effect of the field on the liposome that is not related to heating. Consequently, localized release of drug/chemicals can be effected without subjecting the diseased tissue to adverse heating. In addition, drug/chemical release due to electromagnetic-field treatment of liposomes is enhanced by serum and/or oxygen.
REFERENCES:
patent: 4230129 (1980-10-01), Leveen
patent: 4235871 (1980-11-01), Papahadjopoulos et al.
patent: 4341227 (1982-07-01), Turner
patent: 4425117 (1984-01-01), Hugemann et al.
patent: 4439197 (1984-03-01), Honda et al.
patent: 4448765 (1984-05-01), Ash et al.
patent: 4452775 (1984-06-01), Kent
patent: 4668638 (1987-05-01), Janoff et al.
patent: 4670386 (1987-06-01), Sugaar
Yatvin, Milton B. et al, "Design of Liposomes for Enhanced Local Release of Drugs by Hyperthermia", Science, vol. 202, Dec. 22, 1978, pp. 1290-1292.
Weinstein, J. N. et al, "Liposomes and Local Hyperthermia: Selective Delivery of Methotrexate to Heated Tumors", Science, vol. 204, Apr. 13, 1979, pp. 188-191.
Liburdy, Robert P. et al, "Microwaves and the Cell Membrane, II Temperature, Plasma and Oxygen Mediate Microwave-Induced Membrane Permeability in the Erythrocyte", Radiation Research, 102, 190-205 (1985).
Liburdy, R. P. et al, "Microwave Bioeffects in the Erythrocyte are Temperature and pO.sub.2 Dependent: Cation Permeability and Protein Shedding Occur at the Membrane Phase Transition", Bioelectromagnetics, 5:283-201 (1984).
Liburdy, R. P.: "Microwave-Stimulated Drug Release from Liposomes", Radiation Research, 103, 266-275 (1985).
Erlich Jacob N.
Lovering Richard D.
Singer Donald J.
LandOfFree
Technique for drug and chemical delivery does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Technique for drug and chemical delivery, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Technique for drug and chemical delivery will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-176835