Technique for determining whether a cell is malignant as opposed

Details Technique for determining whether a cell is malignant as opposed Technique for determining whether a cell is malignant as opposed

1994-04-29

1997-06-03

Snay, Jeffrey

Chemistry: analytical and immunological testing

Biological cellular material tested

436 64, 436172, 2504591, 2504612, G01N 2164, G01N 3352

Patent

active

056354029

ABSTRACT:
A technique for determining whether a cell is malignant as opposed to non-malignant using extrinsic fluorescence spectroscopy. The technique is premised on the principle that certain fluorescent dyes preferentially stain malignant cells as opposed to non-malignant cells. Accordingly, by exposing a cell to the fluorescent dye, irradiating the cell with light of such a wavelength as to cause the dye to fluoresce, measuring the intensity of fluorescence at a wavelength indicative of fluorescence of the dye, and comparing the fluorescence intensity to standards obtained from malignant cells and non-malignant cells, it is possible for one to accurately classify the cell as being either malignant or non-malignant. The present invention also relates to an automated system which applies the principles of the aforementioned technique to depict the spatial distribution of cells within an area of a Pap smear-type sample and to characterize each of the cells as being malignant or non-malignant.

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