Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound
Patent
1994-06-27
2000-01-25
Eyler, Yvonne
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
In an organic compound
424 141, 435810, 435975, 435 72, 530324, 530325, 530326, 530327, 530328, 530329, 530330, 514 2, 514 12, 514 13, 514 14, 514 15, 514 16, 514 17, 514 18, A61K 5100, A61M 3614, G01N 3353, G01N 33567
Patent
active
060175109
ABSTRACT:
This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to technetium-99m (Tc-99m) labeled leukocyte-binding peptides, methods and kits for making such peptides, and methods for using such peptides to image sites of infection and inflammation in a mammalian body.
REFERENCES:
patent: 4986979 (1991-01-01), Morgan et al.
patent: 5443815 (1995-08-01), Dean et al.
patent: 5552525 (1996-09-01), Dean
patent: 5711931 (1998-01-01), Dean et al.
Ridikoff et al., Single amino acid substitution altering antigenObinding specificity, PNAS vol. 79:1979-1983, 1982.
Lever et al "Synthesis of a Novel Bifunctional Chelate Designed for Labeling Protein with Technetium-99m" Tetrahedron Letters 29 #26(1988) pp. 3219-3222.
Fritzberg et al "Specific & Stable labeling of antibodies with technetium-99m with a diamide dithiolate chelating agent" Proc. Natl. Acad. Sci 85 (1988) pp. 4025-4029.
Gregoriadis et al (1993) Trends in Biotech. 11:440-442.
* Zoghbi et al., 1981, "Selective cell labeling: a potential radioactive agent for labeling human neutrophils", J. Nucl. Med. 22: 32 (Abst).
* Jiang et al., 1982, "Localization of abscess with an iodinated synthetic chemotactic peptide", Nuklearmedizin 21: 110-113.
* Ebright et al., 1982, "The gallium scan: Problems and misuse in examination of patients with suspsected infection", Arch. Int. Med. 142: 246-254.
* Brenner et al., 1984, "Synthesis and Characterization of a Series of Isomeric Oxotechnetium (V) Diamido Dithiolates", Inorg. Chem. 23: 3793-3797.
* Epps et al., 1987, "Brain Imaging Agents: Synthesis and Characterization of (N-Piperidinylethyl) Hexamethyl Diaminodithiolate Oxo Technetium (V) Complexes" Appl. Radiat. Isot. 38: 661-664.
* Wilkinson, 1988. "Chemotactic factors: an overview", Meth. Enzymol. 162: 127-132.
*Tam, 1988, "Synthetic peptide vaccine design: Synthesis and properties of a high-density multiple antigenic peptide system", Proc. Natl. Acad. Sci. USA 85:5409-5413.
*Fritzberg et al., 1988, "Specific and stable labeling of antibodies with technetium-99m with a diamide dithiolate chelating agent", Proc. Natl. Acad. Sci. USA 85:4025-4029.
* Harlow & Lane, 1988, "Chapter 5: Immunizations", in The Antibodies: A Laboratory Manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., pp. 53-137.
* Vorne et al., 1989, "Technetium-99m HM-PAO-labeled leukocytes in detection of inflammatory lesions: Comparison with gallium-67 citrate", J. Nucl. Med. 30: 1332-1336.
* LaMuraglia et al., 1989, "Utility of the indium 111-labeled human immunoglobulin G scan for the detection of focal vascular graft infection", J. Vac. Surg. 10: 20-28.
* Lind et al., 1990, "Immunoscintigraphy of inflammatory processes with a technetium-99m-labeled monoclonal antigranulocyte antibody (MAb BW 250/183)", J. Nucl. Med. 31: 417-473.
Baidoo & Lever, 1990, "Synthesis of a Diaminedithiol Bifunctional Chelating Agent for Incorporation of Technetium-99m into Biomolecules", Biconjugate Chem. 1: 132-137.
Bryson et al., 1990, "Protecting Groups in the Preparation of Thiolate Complexes of Technetium", Inorganic Chem. 29: 2948-2951.
* Fischman et al., 1991, "Imaging focal sites of bacterial infection in rats with indium-111-labeled chemotactic peptide analogs", J. Nucl. Med. 32: 482-491.
* Peters, 1992, "Imaging inflammation: Current role of labeled autologous leukocytes", J. Nucl. Med. 33: 65-67.
Najifi et al., 1992, "The Evaluation of .sup.186 Re-labeled Antibodies Using N.sub.2 S.sub.4 Chelate In Vitro and In Vivo Using Tumor-bearing Nude Mice", Nucl. Med. Biol. 19:205-212.
Harlow & Lane, 1988, "Chapter 5: Immunzations", in The Antibodies: A Laboratory Manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., pp. 53-137.
Epps et al., 1987, "Brain Imaging Agents: Synthesis and Characterization of (N-Piperidinylethyl) Hexamethyl Diaminodithiolate Oxo Technetium (V) Complexes" Appl. Radiat. Isot. 38: 661-664.
Brenner et al., 1984, "Synthesis and Characterization of a Series of Isomeric Oxotechnetium (V) Diamido Dithiolates", Inorg. Chem. 23: 3793-3797.
Peters, 1992, "Imaging inflammation: Current role of labeled autologous leukocytes", J. Nucl. Med. 33: 65-67.
Fischman et al., 1991, "Imaging focal sites of bacterial infection in rats with indium-111-labeled chemotactic peptide analogs", J. Nucl. Med. 32: 482-491.
Lind et al., 1990, "Immunoscintigraphy of inflammatory processes with a technetium-99-m-labeled monoclonal antigranulocyte antibody (MAb BW 250/183)", J. Nucl. Med. 31: 417-473.
LaMuraglia et al., 1989, "Utility of the indium 111-labeled human immunoglobulin G scan for the detection of focal vascular graft infection", J. Vasc. Surg. 10: 20-28.
Vorne et al., 1989, "Technetium-99m HM-PAO-labeled leukocytes in detection of inflammatory lesions: Comparison with gallium-67 citrate", J. Nucl. Med. 30: 1332-1336.
Wilkinson, 1988, "Chemotactic factors: an overview", Meth. Enzymol. 162: 127-132.
Ebright et al., 1982, "The gallium scan: Problems and misuse in examination of patients with suspected infection", Arch. Int. Med. 142: 246-254.
Jiang et al., 1982, "Localization of abscess with an iodinated synthetic chemotactic peptide", Nuklearmedizin 21: 110-113.
Zoghbi et al., 1981, "Selective cell labeling: a potential radioactive agent for labeling human neutrophils", J. Nucl. Med. 22: 32 (Abst).
Buttram Scott
Dean Richard T.
Lees Robert S.
Diatide, Inc.
Eyler Yvonne
McDaniels Patricia A.
Noonan Kevin E.
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