Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound
Patent
1993-06-07
1996-10-01
Kight, John
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
In an organic compound
530300, 530326, 436808, 534 14, 534 10, A61K 3800, A61K 5100, C07F 1300
Patent
active
055612202
ABSTRACT:
This invention relates to compositions that are radiolabeled scintigraphic imaging agents, comprising a polybasic compound covalently linked to a radiolabel binding moiety and the composition further comprising a polysulfated glycan. The invention also provides methods for producing and using such compositions. Specifically, the invention relates to compositions comprised of technetium-99m (Tc-99m) labeled scintigraphic imaging agents comprising a polybasic compound having at least 5 chemical functionalities that are basic at physiological pH and a radiolabel-binding moiety, the composition further comprising a polysulfated glycan, the composition being capable of specifically binding to inflammatory sites in vivo. Methods and kits for making such compositions, and methods for using such compositions to image sites of infection and inflammation in a mammalian body, are also provided.
REFERENCES:
patent: 4057617 (1977-11-01), Abramovici et al.
patent: 4385046 (1983-05-01), Milbrath et al.
patent: 4444690 (1984-04-01), Fritzberg
patent: 4935223 (1990-06-01), Phillips
patent: 4986979 (1991-01-01), Morgan et al.
patent: 5198424 (1993-03-01), McEver
patent: 5266562 (1993-11-01), Mukherjee et al.
patent: 5308603 (1994-05-01), Thakur
patent: 5376356 (1994-12-01), Morgan, Jr.
Peters, 1992, "Imaging Inflammation: Current role of labeled autologous leukocytes", J. Nucl. Med. 22: 65-67.
Fischman et al., 1991, "Imaging focal sites of bacterial infection in rats with indium-111-labeled chemotactic peptide analogs", J. Nucl. Med. 32: 482-491.
Lind et al., 1990, "Immunoscintigraphy of inflammatory processes with a technetium-99m-labeled monoclonal antigranulocyte antibody (MAb BW 250/183)", J. Nucl. Med. 31: 417-473.
Maione et al., 1989, "Inhibition of Angiogenesis by Recombinant Human Platelet Factor-4 and related Peptides", Science 247: 77-79.
LaMuraglia et al., 1989, "Utility of the indium 111-labeled human immonoglobulin G scan for the detection of focal vascular graft infection", J. Vasc. Surg. 10: 20-28.
Vorne et al., 1989, "Technietium-99m HM-PAO-labeled leukocytes in detection of inflammatory lesions: Comparison with gallium-67 citrate", J. Nucl. Med. 30: 1332-1336.
Bebawy et al., 1986, "In Vitro Effects of Platelet Factor 4 on Normal Human Neutrophil Functions", J. Leukocyte Biol. 39: 423-434.
Loscalzo et al., 1985, "The Interaction of Platelet Factor Four and Glycosaminoglycans", Arch. Biochem. Biophys. 240: 46-455.
Holt & Niewiarowski, 1985, "Biochemistry of .alpha. Granule Proteins", Sem. Hematol. 22: 151-163.
Goldman et al., 1985, "Inhibition of human neutrophil receptor-mediated uptake of N-formyl-met-leu-phe by platelet factor 4 (59-70)", Immunol. 54: 163-171.
Ebright et al., 1982, "The gallium scan: Problems and misuse in examination of patients with suspected infection", Arch. Int. Med. 142: 246-254.
Jiang et al., 1982, "Localization of abscess with an iodinated synthetic chemotactic peptide", Nuklearmedizin 21: 110-113.
Osterman et al., 1982, "The Carboxyl-terminal Tridecapeptide of Platelet Factor 4 is a Potent Chemotactic Agent for Monocytes", Biochem. Biophys. Res. Comm. 107: 130-135.
Deuel et al., 1981, "Platelet factor 4 is chemotactic for neutrophils and monocytes", Proc. Natl. Acad. Sci. USA 78: 4584-4587.
Zoghbi et al., 1981, "Selective cell labeling: A potential radioactive agent for labeling human neutrophils", J. Nucl. Med. 22: 32 (Abst).
Niedel and Cuatrecasas, 1980, "Formyl Peptide Chemotactic Receptors of Leukocytes and Macrophages", in Curr. Top. Cell. Reg. 17: 137-170.
Deuel et al., 1977, "Amino acid sequence of human platelet factor 4", Proc. Natl. Acad. Sci. USA 74: 2256-2258.
Takefumi et al, Molecular & Cellular Biology, pp. 898-904, (1987).
Dean Richard T.
Moyer Brian R.
Diatech Inc.
Kight John
Leary Louise N.
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